5-aroylpyrrol-2-ylmethylarene derivatives

ABSTRACT

Compounds selected from the group of compounds represented by formula I: ##STR1## where: R 10  is represented by the formula (A), (B), or (C): ##STR2## R 20  is represented by the formula (U), (V), or (W): ##STR3## and the other substituents are as defined in the specification; and their pharmaceutically acceptable salts; are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims the benefit under 35 U.S.C. 119(e) of U.S.Provisional Application No. 60/018,691, filed May 30, 1996.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to anti-inflammatory and analgesic compounds;especially to certain 5-aroylpyrrol-2-ylmethylarene derivatives,pharmaceutical compositions containing them, methods for their use andmethods for preparing these compounds.

2. Description of the Related Art

U.S. Pat. No. 3,752,826 (Carson) discloses 5-aroylpyrrol-2-ylalkanoicacids and derivatives useful as anti-inflammatory agents.

European Patent Application Publication No. 0 071 399 (Syntex (U.S.A.)Inc.) discloses 2-benzyl-5-phenylpyrrolidine derivatives and analogsuseful as cardiovascular agents and bronchodilators.

SUMMARY OF THE INVENTION

In a first aspect, this invention provides compounds selected from thegroup of compounds represented by formula I: ##STR4## where:

R₁ and R₅ are independently H or alkyl, or R₁ and R₅ together are--(CH₂)₂ -- or --(CH₂)₃ --;

R₃ and R₄ are independently H, halo, alkyl, alkyloxy, or alkylthio;

R₁₀ is a group represented by formula (A), (B), or (C): ##STR5## where:

X is O or S;

R₁₂ and R₁₆ are independently H, halo, alkyl, alkyloxy, alkylthio,cyano, or hydroxy;

R₁₃ and R₁₅ are independently H, halo, alkyl, alkyloxy, or alkylthio;and

R₁₄ is H, halo, alkyl, haloalkyl, amino, alkylamino, dialkylamino,alkyloxy, hydroxy, alkylthio, alkenyl, alkynyl, cyano, --SO₂ R₁₇ whereR₁₇ is alkyl, or --SO₂ NR₁₈ R₁₉ where R₁₈ and R₁₉ are independently H oralkyl;

provided that at least two of R₁₂, R₁₃, R₁₄, R₁₅, and R₁₆ are H, andthat if only two of R₁₂, R₁₃, R₁₄, R₁₅, and R₁₆ are H, the non-hydrogensubstituents are not all adjacent; or R₁₂, R₁₅, and R₁₆ are H and R₁₃and R₁₄ together are --OCH₂)--;

R₂₀ is a group represented by formula (U), (V), or (W): ##STR6## where:

R₂₂ is H, halo, alkyl, cyano, trifluoromethyl, hydroxy, alkyloxy, or--CO₂ R₂₇ where R₂₇ is H or alkyl;

one of R₂₃, R₂₄, and R₂₅ is R₃₀ ; and

either all the remaining R₂₃, R₂₄, R₂₅, and R₂₆ are H; or one of theremaining R₂₃, R₂₄, R₂₅, and R₂₆ is halo, alkyl, cyano, trifluoromethyl,hydroxy, or alkyloxy; and

R₃₀ is --OH*, --NHH*, --NH*CHO, --NH*C(X)R₃₁, --NH*SO₂ R₃₁,--NH*C(X)NR₃₂ R₃₃, or --NH*SO₂ NR₃₂ R₃₄ ;

where:

H* is hydrogen, optionally replaced by an in vivo hydrolyzableprotecting group;

R₃₁ is alkyl, haloalkyl, hydroxyalkyl, alkenyl, benzyl, aryl,cycloamino, --CH₂ SO₂ Me, or --(CH₂)_(n) R₃₅ where n is an integer from2 to 5 and R₃₅ is alkylamino, dialkylamino, cycloamino, alkyloxy,acyloxy, or --CO₂ R₂₇ ;

R₃₂ is H, alkyl, or --(CH₂)_(n) OR₂₇ ;

R₃₃ is H, alkyl, haloalkyl, aryl, hydroxyalkyl,tetrahydrofuran-2-ylmethyl, --CH₂ CO₂ R₂₇, or --(CH₂)_(n) R₃₅ ; and

R₃₄ is H, alkyl, acetyl, hydroxyalkyl, or --(CH₂)_(n) R₃₅ ; and theirpharmaceutically acceptable salts.

In a second aspect, this invention provides pharmaceutical compositionscontaining a therapeutically effective amount of a compound of formula Ior its pharmaceutically acceptable salt and a pharmaceuticallyacceptable excipient.

In a third aspect, this invention provides a method of treatment of adisease, in particular inflammatory and autoimmune diseases, in a mammaltreatable by administration of a prostaglandin G/H synthase inhibitor,comprising administration of a therapeutically effective amount of acompound of formula I or its pharmaceutically acceptable salt.

DETAILED DESCRIPTION OF THE INVENTION Definitions

Unless otherwise stated, the following terms used in the specificationand claims have the meanings given below:

"Alkyl" means a linear saturated monovalent hydrocarbon radical of oneto six carbon atoms; or a branched or cyclic saturated monovalenthydrocarbon radical of three to six carbon atoms, e.g., methyl, ethyl,propyl, 2-propyl, cyclopropyl, cyclopropylmethyl, pentyl, and the like.

"Alkyloxy" means a radical --OR where R is alkyl, e.g., methoxy, ethoxy,propoxy, 2-propoxy, and the like.

"Alkylthio" means a radical --SR where R is alkyl, e.g., methylthio,butylthio, and the like.

"Acyloxy" means a radical --OC(O)R where R is alkyl, e.g., acetoxy,propionyloxy and the like.

"Alkenyl" means a linear monovalent hydrocarbon radical of two to sixcarbon atoms or a branched monovalent hydrocarbon radical of three tosix carbon atoms, containing a double bond, e.g., ethenyl, propenyl, andthe like.

"Alkynyl" means a linear monovalent hydrocarbon radical of two to sixcarbon atoms or a branched monovalent hydrocarbon radical of three tosix carbon atoms, containing a triple bond, e.g., ethynyl, propynyl,butynyl, and the like.

"Halo" means fluoro, bromo, chloro and iodo, preferably fluoro andchloro.

"Haloalkyl" means alkyl substituted with one to three fluorine orchlorine atoms, e.g., --CH₂ Cl, --CF₃, --CH₂ CF₃, --CH₂ CCl₃, and thelike.

"Alkylamino" means a radical --NHR where R is alkyl, e.g., methylamino,(1-methylethyl)amino, and the like.

"Dialkylamino" means a radical --NRR' where R and R' are independentlyalkyl, e.g., dimethylamino, methylethylamino, di(1-methylethyl)amino,and the like.

"Cycloamino" means a saturated monovalent, cyclic radical of 5 or 6 ringatoms of which the bonding ring atom is N; one non-adjacent other ringatom is NR (where R is hydrogen or alkyl), O, or C; and the remainingring atoms are C. Examples include 1-pyrrolidino, 1-piperidino,1-piperazino, N-methylpiperazino, 4-morpholino, and the like.

"Hydroxyalkyl" means a linear monovalent hydrocarbon radical of two tofour carbon atoms or a branched monovalent hydrocarbon radical of threeor four carbons substituted with one or two hydroxy groups, providedthat: (1) the bonding carbon is unsubstituted, and (2) if two hydroxygroups are present, they are not both on the same carbon atom. Examplesinclude 2-hydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl,2-hydroxybutyl, 3-hydroxybutyl, 4-hydroxybutyl, 2,3-dihydroxypropyl,1-(hydroxymethyl)-2-hydroxyethyl, 2,3-dihydroxybutyl, 3,4-dihydroxybutyland 2-(hydroxymethyl)-3-hydroxypropyl, preferably 2-hydroxyethyl,2,3-dihydroxypropyl, and 1-(hydroxymethyl)-2-hydroxyethyl.

"Aryl" means a monovalent aromatic hydrocarbon radical of 5 or 6 ringatoms, optionally containing one ring heteroatom selected from NR (whereR is H or alkyl), O or S, and optionally mono- or di-substitutedindependently with --OH, --COOH, alkyl, alkyloxy, alkylthio, fluoro,chloro, --CF₃, and cyano; e.g., phenyl, thienyl, pyridyl, furanyl,3-chlorophenyl, 4-(methylthio)phenyl, and the like.

An "in vivo hydrolyzable protecting group" means a group, replacing anacidic proton (such as a phenolic or amino proton) in a compound offormula I, that is capable of undergoing enzymatic hydrolysis within aliving organism to form the unprotected (proton-containing) compound offormula I in vivo. Preferred in vivo hydrolyzable protecting groups are--C(O)R, where R is alkyl, or --C(O)CH(NH₂)R", where R" is the sidechain of a D or L natural amino acid e.g., for alanine, R" is methyl;for lysine, R" is --(CH₂)₄ NH₂ !. Preferred R" groups are methyl,isopropyl and benzyl.

"Optional" or "optionally" means that the subsequently described eventor circumstance may but need not occur, and that the descriptionincludes instances where the event or circumstance occurs and instancesin which it does not. For example, "--OH* where H* is optionallyreplaced by an in vivo hydrolyzable protecting group" means that the invivo hydrolyzable protecting group may but need not be present, and thedescription includes situations where --OH* is present as --OH,--OC(O)R, or --OC(O)CH(NH₂)R" where --C(O)R and --C(O)CH(NH₂)R" are invivo hydrolyzable protecting groups as defined above.

A "pharmaceutically acceptable excipient" means an excipient that isuseful in preparing a pharmaceutical composition that is generally safe,non-toxic and neither biologically nor otherwise undesirable, andincludes an excipient that is acceptable for veterinary use as well ashuman pharmaceutical use. "A pharmaceutically acceptable excipient" asused in the specification and claims includes both one and more than onesuch excipient

A "pharmaceutically acceptable salt" of a compound means a salt that ispharmaceutically acceptable and that possesses the desiredpharmacological activity of the parent compound. Such salts include:

(1) acid addition salts, formed with inorganic acids such ashydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid,phosphoric acid, and the like; or formed with organic acids such asacetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid,glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid,malic acid, maleic acid, fumaric acid, tartaric acid, citric acid,benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelicacid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethanedisulfonicacid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid,4-chlorobenzenesulfonic acid, 2-napthalenesulfonic acid,4-toluenesulfonic acid, camphorsulfonic acid, 4-methylbicyclo2.2.2!oct-2-ene-1-carboxylic acid, glucoheptonic acid,4,4'-methylenebis- (3-hydroxy-2-ene-1-carboxylic acid),3-phenylpropionic acid, trimethylacetic acid, tertiary butylacetic acid,lauryl sulfuric acid, gluconic acid, glutamic acid, hydroxynapthoicacid, salicylic acid, stearic acid, muconic acid, and the like; or

(2) salts formed when an acidic proton present in the parent compoundeither is replaced by a metal ion, e.g., an alkali metal ion, analkaline earth ion, or an aluminum ion; or coordinates with an organicbase such as ethanolamine, diethanolamine, triethanolamine,tromethamine, N-methylglucamine, and the like.

"Treating" or "treatment" of a disease includes:

(1) preventing the disease, i.e. causing the clinical symptoms of thedisease not to develop in a mammal that may be exposed to or predisposedto the disease but does not yet experience or display symptoms of thedisease,

(2) inhibiting the disease, i.e., arresting the development of thedisease or its clinical symptoms, or

(3) relieving the disease, i.e., causing regression of the disease orits clinical symptoms.

A "therapeutically effective amount" means the amount of a compoundthat, when administered to a mammal for treating a disease, issufficient to effect such treatment for the disease. The"therapeutically effective amount" will vary depending on the compound,the disease and its severity and the age, weight, etc., of the mammal tobe treated.

"Me" denotes methyl.

Nomenclature

The naming and numbering of the compounds of this invention isillustrated below. The pyrrole and the side chain of R₂₀ nucleus of thecompounds of formula I are numbered as follows: ##STR7##

Side chains of the R₁₀ substituent are numbered as shown below: ##STR8##

The pyridine, thiophene, and furan rings can be linked to the pyrrolecarbonyl group at any position on the ring other than 1-position.Accordingly, the pyridine ring can be 2-, 3-, or 4-pyridyl, thethiophene ring can be 2- or 3-thienyl, and the furan ring can be 2- or3-furyl.

The nomenclature used in this application is generally based on theIUPAC recommendations. However, because a strict adherence to theserecommendations would result in the names changing substantially whenonly a single substituent is changed, compounds have been named in aform that maintains consistency of nomenclature for the basic structureof the molecule.

Representative compounds of this invention are as follows:

Ia. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₅═H, R₁₄ ═Cl; R₁₀ ═group represented by formula (A); R₂₀ ═grouprepresented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ R₃₁, are:

    ______________________________________    CPD#  R.sub.5                 R.sub.22                         R.sub.23                              R.sub.26                                   R.sub.31  M.Pt. ° C.    ______________________________________    1     H      H       H    H    Me        200.9-202    2     H      H       H    H    CF.sub.3  159.5-160.2    3     H      H       H    H    CH.sub.2 CH.sub.3                                             152.1-152.9    4     H      H       H    H    (CH.sub.2).sub.2 NMe.sub.2.HCl                                             232.5-232.7    5     H      H       H    H    (CH.sub.2).sub.2 CO.sub.2 Me                                             147.6-148.2    6     H      H       H    H    (CH.sub.2).sub.2 CO.sub.2 H                                             211    7     H      H       H    H    (CH.sub.2).sub.2 OH                                             132.2-134    8     H      H       H    H    (CH.sub.2).sub.2 -morpho-                                             243.4-243.7                                   line.HCl    9     H      H       H    H    CH═CH.sub.2                                             146.8-147    10    H      H       H    H    CH.sub.2 SO.sub.2 Me                                             187-188    11    Me     H       H    H    Me        foam    12    H      Me      H    H    Me        190-191    13    H      CF.sub.3                         H    H    Me        204-206    14    H      Cl      H    H    Me        215-217    15    H      CO.sub.2 Me                         H    H    Me        197-199    16    H      CO.sub.2 H                         H    H    Me        248-250    17    H      F       H    H    Me        211-212    18    H      OMe     H    H    Me        164-165    19    H      CN      H    H    Me        204    20    H      F       H    H    CH.sub.2 CH.sub.3                                             151-151.3    21    H      H       Me   H    Me        175-177    22    H      H       F    H    Me        183-185    23    H      H       OH   H    Me        205    24    H      H       CN   H    Me        187    25    H      Cl      H    H    (CH.sub.2).sub.2 OH                                             159    26    H      H       H    H    Me H*═COMe                                             196    27    H      F       H    F    Me        242.8-243.5    ______________________________________

and are named as follows:

1. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methane-sulfonamide.

2. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}trifluoro-methanesulfonamide.

3. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}ethanesulfonamide.

4. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(dimethylamino)-ethanesulfonamidehydrochloride.

5. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(methoxy-carbonyl)ethanesulfonamide.

6. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(carboxy)-ethanesulfonamide.

7. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

8. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(morpholin-4yl)ethanesulfonamidehydrochloride.

9. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}ethenesulfonamide.

10. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-C-(methylsulfonyl)-methanesulfonamide.

11. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylethan-1-yl!phenyl}-methanesulfonamide,m/e=430(M+).

12. N-{3-Methyl-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

13. N-{3-Trifluoromethyl-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

14. N-{3-Chloro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

15. N-{3-Carboxymethyl-4-5-(4-chlorobenzoyl)-1,4dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

16. N-{3-Carboxy-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

17. N-{3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

18. N-{3-Methoxy-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

19. N-{3-Cyano-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

20. N-{3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethanesulfonamide.

21. N-{2-Methyl-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

22. N-{2-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

23. N-{2-Hydroxy-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

24. N-{2-Cyano-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

25. N-{3-Chloro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

26. N-Methoxycarbonyl-N-{4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!-phenyl}-methanesulfonamide.

27. N-{3,5-Difluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!-phenyl}-methanesulfonamide.

Ib. Compounds of formula I where R₁ ═Me; R₄ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₃ ═R₂₅ ═H;R₁₄ ═Me; R₁₀ ═is a group represented by formula (A); R₂₀ ═is a grouprepresented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ R₃₁, are:

    ______________________________________    CPD#  R.sub.3                R.sub.5                       R.sub.12                            R.sub.22                                 R.sub.26                                      R.sub.31 M.Pt. ° C.    ______________________________________    28    H     H      H    H    H    Me       138-139    29    H     H      H    H    H    (CH.sub.2).sub.2 OH                                               foam    30    H     Me     H    H    H    Me       147-148    31    H     H      H    Cl   H    Me       137-139    32    H     H      H    CF.sub.3                                 H    Me       172-174    33    H     H      H    Br   H    Me       160-161    34    H     H      H    CN   H    Me       171-172    35    H     H      H    F    H    Me       164.8-165.3    36    H     H      H    F    H    (CH.sub.2).sub.2 OH                                               foam    37    H     H      H    Cl   H    (CH.sub.2).sub.2 OH                                               123-125    38    Me    H      H    F    H    Me       200.8-201.6    39    Me    H      H    F    H    CH.sub.2 CH.sub.3                                               140.4-141.9    40    Me    H      H    CN   H    Me       204.3-207.4    41    H     H      Me   F    H    Me       159.6-160.0    42    H     H      H    F    H    CH(CH.sub.2 OH).sub.2                                               133.3-133.6    43    Me    H      Me   Cl   H    Me       191.8-192.4    44    H     H      H    F    H    (CH.sub.2)3OH                                               116.7-119.8    45    Me    H      Me   CN   H    Me       203-205.2    46    Me    H      H    F    H    (CH.sub.2).sub.2 OH                                               151.5-152.9    47    Me    H      H    Cl   H    Me       208.4-209.4    48    H     H      Me   F    H    (CH.sub.2).sub.2 OH                                               135.4-136.8    49    Me    H      Me   F    H    Me       198.3-199    50    H     H      Me   H    H    (CH.sub.2).sub.2 OH                                               63-66    51    H     H      H    F    F    (CH.sub.2).sub.2 OH                                               154.2-155.2    52    H     H      H    F    F    Me       205.5-206.2    53    H     H      OMe  F    H    (CH.sub.2).sub.2 OH                                               70.5-76    ______________________________________

and are named as follows:

28. N-{4-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

29. N-{4-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide,m/e=412(M+).

30. N-{4-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylethan-1-yl!phenyl}methanesulfonamide.

31. N-{3-Chloro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

32. N-{3-Trifluoromethyl-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

33. N-{3-Bromo-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

34. N-{3-Cyano-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

35. N-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

36. N-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide,m/e=430(M+).

37. N-{3-Chloro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

38. N-{3-Fluoro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

39. N-{3-Fluoro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethanesulfonamide.

40. N-{3-Cyano-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

41. N-{3-Fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

42. N-{3-Fluoro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-1-(hydroxymethyl)-2-(hydroxy)ethanesulfonamide.

43. N-{3-Chloro-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

44. N-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(hydroxy)propanesulfonamide.

45. N-{3-Cyano-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

46. N-{3-Fluoro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

47. N-{3-Chloro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

48. N-{3-Fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

49. N-{3-Fluoro-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

50. N-{4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

51. N-{3,5-Difluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

52. N-{3,5-Difluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide

53. N-{3-Fluoro-4-5-(2-methoxy-4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide

Ic. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₃ ═R₂₅═H; R₁₄ ═H; R₁₀ ═is a group represented by formula (A); R₂₀ ═is a grouprepresented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ R₃₁, are:

    ______________________________________    CPD#  R.sub.3                 R.sub.12                        R.sub.22                             R.sub.26                                   R.sub.31  M.Pt. ° C.    ______________________________________    54    Me     H      H    H     Me        149-150    55    Me     H      H    H     (CH.sub.2).sub.2 CO.sub.2 Me                                             121.5-121.9    56    Me     H      H    H     (CH.sub.2).sub.2 CO.sub.2 H                                             181    57    Me     H      H    H     (CH.sub.2).sub.2 OH                                             158.2-158.6    58    Me     H      H    H     CH.sub.2 CH.sub.3                                             117.7-118.8    59    Me     H      Cl   H     Me        177-179    60    Me     H      F    H     Me        167-168    61    Me     H      OMe  H     Me        133-134    62    Me     H      CF.sub.3                             H     Me        170-171    63    Me     H      F    H     (CH.sub.2).sub.2 OH                                             149-149.3    64    H      H      H    H     Me        137-138    65    H      H      F    H     Me        137.2-137.5    66    H      H      F    H     (CH.sub.2).sub.2 OH                                             foam    67    Me     H      F    H     Me H*═COMe                                             172    68    Me     H      F    H     CH.sub.2 CH.sub.3                                             141.1-143.1    69    H      H      Cl   H     (CH.sub.2).sub.2 OH                                             149.9-151.1    70    H      H      Cl   H     Me        180.2-181.6    71    H      Me     F    H     Me        178.7-179.2    72    H      OMe    F    H     Me        184.4-184.9    73    H      OMe    F    H     (CH.sub.2).sub.2 OH                                             foam    74    H      F      F    H     Me        140-141    75    H      H      F    F     Me        192.6-193.1    76    H      Cl     F    H     (CH.sub.2).sub.2 OH                                             55.5-58.5    77    H      F      F    H     (CH.sub.2).sub.2 OH                                             54.2-58.1    78    H      H      F    F     C.sub.2 H.sub.5                                             138.5-139.4    79    Me     H      F    F     (CH.sub.2).sub.2 OH                                             171-173.8    80    H      H      F    F     (CH.sub.2).sub.2 OH                                             156.5-157    ______________________________________

and are named as follows:

54. N-{4-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

55. N-{4-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(methoxycarbonyl)-ethanesulfonamide.

56. N-{4-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(carboxy)ethane-sulfonamide.

57. N-{4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethane-sulfonamide.

58. N-{4-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}ethanesulfonamide

59. N-{3-Chloro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

60. N-{3-Fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

61. N-{3-Methoxy-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methane-sulfonamide.

62. N-{3-Trifluoromethyl-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

63. N-{3-Fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

64. N-{4-5-Benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

65. N-{3-Fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

66. N-{3-Fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide,m/e=416(M+).

67. N-Acetyl-N-{3-Fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

68. N-{3-Fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}ethanesulfonamide.

69. N-{3-Chloro-4- 5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

70. N-{3-Chloro-4- 5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

71. N-{3-Fluoro-4-5-(2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

72. N-{3-Fluoro-4-5-(2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

73. N-{3-Fluoro-4-5-(2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide,m/e=446(M+).

74. N-{3-Fluoro-4-5-(2-fluorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

75. N-{3,5-Difluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

76. N-{3-Fluoro-4-5-(2-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

77. N-{3-Fluoro-4-5-(2-fluorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

78. N-{3,5-Difluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}ethanesulfonamide.

79. N-{3,5-Difluoro-4-5-benzoyl-1,4dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

80. N-{3,5-Difluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

Id. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₃ ═R₂₅═R₂₆ ═H; R₁₀ ═is a presented by formula (A); R₂₀ ═is a group representedby formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ R₃₁, are:

    ______________________________________    CPD#  R.sub.12                 R.sub.14 R.sub.3                               R.sub.22                                    R.sub.31 M.Pt. ° C.    ______________________________________    81    H      NMe.sub.2                          H    H    Me       210-211    82    H      Cl       H    H    Me       164    83    H      Br       H    H    Me       169-170    84    Me     Me       H    H    Me       129-130    85    H      OMe      H    H    Me       147-148    86    H      SMe      H    H    Me       185-186    87    H      NH.sub.2 H    H    Me       203.3-205    88    H      NMe.sub.2                          H    F    Me       199    89    H      NMe.sub.2                          H    CN   Me       203    90    H      CH.sub.2 CH.sub.3                          H    H    Me       115-116    91    H      cyclo-   H    H    Me       foam                 propyl    92    Me     H        Me   H    Me       149-151    93    H      SMe      Me   H    Me       182.6-183.3    94    H      SMe      Me   H    CH.sub.2 CH.sub.3 Na.sup.+                                             >280    95    H      OMe      Me   F    Me       186.6-187.5    96    H      OMe      H    F    Me       180.9-181.8    97    H      OMe      Me   F    CH.sub.2 CH.sub.3                                             109-110    98    H      OMe      Me   F    (CH.sub.2).sub.2 OH                                             139.5-140.5    99    H      OMe      H    CN   Me       164.7-166.7    100   H      SMe      Me   F    CH.sub.2 CH.sub.3                                             148.1-148.7    101   H      F        Me   F    Me       169.2-169.7    102   H      F        Me   F    CH.sub.2 CH.sub.3                                             138.2-139.2    103   H      SMe      Me   F    Me       188.8-189.5    104   H      F        Me   F    (CH.sub.2).sub.2 CH                                             139.1-140.2    105   H      OMe      Me   F    CH═CH.sub.2                                             90-92    106   H      OMe      H    F    (CH.sub.2).sub.2 CH                                             135-137    107   H      SMe      Me   F    (CH.sub.2).sub.2 OCOMe                                             146.2-146.7    108   H      SMe      Me   F    (CH.sub.2).sub.2 OH                                             174.9-175.5    109   H      CF.sub.3 Me   F    Me       177-177.8    110   H      CF.sub.3 Me   F    CH.sub.2 CH.sub.3                                             132.4-133.2    111   H      cyclo-   H    F    Me       140.5-142                 propyl    112   H      CF.sub.3 Me   Cl   Me       203-204.8    113   Cl     OMe      H    F    Me       150-151    114   Cl     OMe      H    F    (CH.sub.2).sub.2 CH    115   F      F        H    F    Me       168.4-169.1    116   F      F        H    F    (CH.sub.2).sub.2 OH                                             80-84    117   H      OC.sub.2 H.sub.5                          H    F    Me       134.6-134.9    118   OMe    F        H    F    Me       162-162.3    119   H      OC.sub.2 H.sub.5                          H    F    CH.sub.2 CH.sub.3                                             135.3-135.6    120   OMe    F        H    F    (CH.sub.2).sub.2 CH                                             58.1-64.1    121   H      OC.sub.2 H.sub.5                          H    F    (CH.sub.2).sub.2 OH                                             105-106.5    122   Me     OMe      H    F    Me       149.5-150.1    123   Me     OMe      H    F    (CH.sub.2).sub.2 OH                                             56.3-61.7    124   Me     Br       H    F    Me       177.5-178    125   Me     Br       H    F    (CH.sub.2).sub.2 OH                                             70.5-71.5    126   F      OMe      H    F    Me       164.5-165.1    127   H      Br       H    F    Me       178.6-179.5    128   H      Br       H    F    (CH.sub.2).sub.2 OH                                             53.5-56    129   H      Cl       H    F    Me       175.4-176.1    130   H      Cl       H    F    (CH.sub.2).sub.2 OH                                             143.1-144    ______________________________________

and are named as follows:

81. N-{4-5-(4-Dimethylaminobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methane-sulfonamide.

82. N-{4-5-(4-Chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

83. N-{4-5-(4-Bromobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

84. N-{4-5-(2,4-Dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

85. N-{4-5-(4-Methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-phenyl}methanesulfonamide.

86. N-{4-5-(4-Methylthiobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methane-sulfonamide.

87. N-{4-5-(4-Aminobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

88. N-{3-Fluoro-4-5-(4-dimethylaminobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

89. N-{3-Cyano-4-5-(4-dimethylaminobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

90. N-{4-5-(4-Ethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

91. N-{4-5-(4-Cyclopropylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

92. N-{4-5-(2-Methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

93. N-{4-5-(4-Methylthiobenzoyl)-1,4dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methane-sulfonamide.

94. N-{4-5-(4-Methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}ethane-sulfonamidesodium salt.

95. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

96. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

97. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethanesulfonamide.

98. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

99. N-{3-Cyano-4-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

100. N-{3-Fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethanesulfonamide.

101. N-{3-Fluoro-4-5-(4-fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

102. N-{3-Fluoro-4-5-(4-fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethanesulfonamide.

103. N-{3-Fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

104. N-{3-Fluoro-4-5-(4-fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

105. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethenesulfonamide.

106. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

107. N-{3-Fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(acetoxy)ethanesulfonamide.

108. N-{3-Fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

109. N-{3-Fluoro-4-5-(4-trifluoromethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

110. N-{3-Fluoro-4-5-(4-trifluoromethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethanesulfonamide.

111. N-{3-Fluoro-4-5-(4-cyclopropylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

112. N-{3-Chloro-4-5-(4-trifluoromethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

113. N-{3-Fluoro-4-5-(2-chloro-4-methoxylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

114. N-{3-Fluoro-4-5-(2-chloro-4-methoxylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide,m/e=481(M+H).

115. N-{3-Fluoro-4-5-(2,4-difluorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

116. N-{3-Fluoro-4-5-(2,4-difluorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

117. N-{3-Fluoro-4-5-(4-ethoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

118. N-{3-Fluoro-4-5-(4-fluoro-2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

119. N-{3-Fluoro-4-5-(4-ethoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-ethanesulfonamide.

120. N-{3-Fluoro-4-5-(4-fluoro-2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

121. N-{3-Fluoro-4-5-(4-ethoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

122. N-{3-Fluoro-4-5-(4-methoxy-2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

123. N-{3-Fluoro-4-5-(4-methoxy-2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

124. N-{3-Fluoro-4-5-(4-bromo-2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

125. N-{3-Fluoro-4-5-(4-bromo-2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

126. N-{3-Fluoro-4-5-(2-fluoro-4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

127. N-{3-Fluoro-4-5-(4-bromobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

128. N-{3-Fluoro-4-5-(4-bromobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

129. N-{3-Fluoro-4-5-(4-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

130. N-{3-Fluoro-4-5-(4-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

Ie. Compounds of formula I where R₁ +R₅ ═(CH₂)₂ --; R₃ ═R₄ ═R₁₂ ═R₁₃═R₁₅ ═R₁₆ ═R₂₃ ═R₂₅ ═R₂₆ ═H; R₁₀ ═is a group represented by formula (A);R₂₀ ═is a group represented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ R₃₁,are:

    ______________________________________    CPD#      R.sub.14 R.sub.22                               R.sub.31 M.Pt. ° C.    ______________________________________    131       H        Cl      Me       85-95    132       OMe      Cl      Me       183-183.5    133       OMe      Cl      (CH.sub.2).sub.2 OH                                        74.5-84.5    134       H        Cl      (CH.sub.2).sub.2 OH                                        80.5-109    135       H        F       Me       162-162.8    136       OMe      H       Me       146-147.1    137       OMe      F       (CH.sub.2).sub.2 OH                                        146-147.1    138       OMe      F       Me       159-162    139       H        F       (CH.sub.2).sub.2 OH                                        159-161.5    ______________________________________

and are named as follows:

131. N-{3-Chloro-4-5-Benzoyl-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}methanesulfonamide.

132. N-{3-Chloro-4-5-(4-methoxybenzoyl)-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}-methanesulfonamide.

133. N-{3-Chloro-4-5-(4-methoxybenzoyl)-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}-2(hydroxy)ethanesulfonamide.

134. N-{3-Chloro-4-5-benzoyl-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}-2-(hydroxy)-ethanesulfonamide.

135. N-{3-Fluoro-4-5-benzoyl-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}methanesulfonamide.

136. N-{4-5-(4-methoxybenzoyl)-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}methanesulfonamide.

137. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}-2-(hydroxy)-ethanesulfonamide.

138. N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}-methanesulfonamide.

139. N-{3-Fluoro-4-5-benzoyl-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}-2-(hydroxy)-ethanesulfonamide.

IIa. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆═R₂₃ ═R₂₅ ═R₂₆ ═H; R₁₄ ═Cl; R₁₀ ═is a group represented by formula (A);R₂₀ ═is a group represented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ NR₃₂R₃₄, are:

    ______________________________________    CPD#     R.sub.22 R.sub.32  R.sub.34                                        M.Pt. ° C.    ______________________________________    140      H        Me        Me      57-142    141      H        H         H       175-177    132      H        H         COCH.sub.3                                        164.5-170    143      H        (CH.sub.2).sub.2 OH                                (CH.sub.2).sub.2 OH                                        122-124    144      Cl       Me        Me      175-177    145      F        Me        Me      185-186    146      F        H         H       179.8-180    147      CN       H         H       192    148      Cl       H         H       179-180    ______________________________________

and are named as follows:

140. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

141. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

142. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-acetylsulfamide.

143. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!-phenyl}-3,3-bis-(2-hydroxyethyl)sulfamide.

144. 1-{3-Chloro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

145. 1-{3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

146. 1-{3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

147. 1-{3-Cyano-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

148. 1-{3-Chloro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

IIb. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₁₅ αR₁₆ ═R₂₃═R₂₅ ═H; R₁₄ ═Me; R₁₀ ═is a group represented by formula (A); R₂₀ ═is agroup represented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ NR₃₂ R₃₄, are:

    ______________________________________    CPD    #    R.sub.3               R.sub.12                      R.sub.22                           R.sub.26                                R.sub.32                                       R.sub.34                                               M.Pt. ° C.    ______________________________________    149  H     H      H    H    Me     Me      130-139    150  H     H      H    H    H      H       152-152.8    151  H     H      Cl   H    Me     Me      157-159    152  H     H      CF.sub.3                           H    Me     Me      114-115    153  H     H      Br   H    Me     Me      157-158    154  H     H      F    H    H      H       153.1-153.9    155  H     H      F    H    Me     Me      158-158.9    156  H     H      Cl   H    H      H       166.3-166.9    157  H     H      F    H    (CH.sub.2).sub.2 OH                                       (CH.sub.2).sub.2 OH                                               108.4-108.7    158  H     H      F    H    H      Me      foam    159  H     H      F    H    H      CH.sub.2 CH.sub.3                                               foam    160  H     H      F    H    H      (CH.sub.2).sub.2 OMe                                               foam    161  Me    H      F    H    H      Me      166.5-167.    162  Me    H      F    H    H      H       189.5-189.9    163  Me    H      F    H    Me     Me      169.6-170.5    164  H     H      F    H    H      (CH.sub.2).sub.2 OH                                               120.2-121.8    165  H     Me     F    H    H      H       149-152    166  Me    Me     Cl   H    Me     Me      58.9-61.8    167  Me    Me     Cl   H    H      H       76.5-80.2    168  H     Me     H    H    H      CH.sub.2 CH.sub.3                                               66-70    169  H     Me     H    H    H      H       77-88.6    170  H     Me     H    H    H      Me      76-80    171  Me    Me     CN   H    H      H       161.5-165    172  H     Me     F    H    H      Me      65.1-67.5    173  Me    Me     CN   H    Me     Me      67-71    174  H     H      F    F    H      H       202.2-202.8    175  H     Me     F    H    H      COCH.sub.3                                               94-97.5    ______________________________________

and are named as follows:

149. 1-{4-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

150. 1-{4-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

151. 1-{3-Chloro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

152. 1-{3-Trifluoromethyl-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

153. 1-{3-Bromo-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

154. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

155. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

156. 1-{3-Chloro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

157. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-bis-(2-hydroxyethyl)sulfamide.

158. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methyl-sulfamide,m/e =415(M+).

159. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-ethyl-sulfamide,m/e=429(M+).

160. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(2-methoxyethyl)sulfamide,m/e=459(M+).

161. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methyl-sulfamide.

162. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

163. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

164. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(2-hydroxyethyl)sulfamide.

165. 1-{3-Fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

166. 1-{3-Chloro-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

167. 1-{3-Chloro-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

168. 1-{4-5-(2,4-Dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-ethylsulfamide.

169. 1-{4-5-(2,4-Dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

170. 1-{4-5-(2,4-Dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

171. 1-{3-Cyano-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

172. 1-{3-Fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

173. 1-{3-Cyano-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

174. 1-{3,5-Difluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

175. 1-{3-Fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-acetyl-sulfamide.

IIc. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₃═R₂₅ ═H, R₁₄ ═H; R₁₀ ═is presented by formula (A); R₂₀ ═is a grouprepresented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ NR₃₂ R₃₄, are:

    ______________________________________    CPD#   R.sub.3                 R.sub.12                         R.sub.22                              R.sub.26                                    R.sub.32                                         R.sub.34                                               M.Pt. ° C.    ______________________________________    176    Me    H       H    H     Me   Me    126.5-127.4    177    Me    H       H    H     H    H     179.1-180    178    Me    H       Cl   H     Me   Me    185-187    179    Me    H       F    H     Me   Me    182-183    180    Me    H       OMe  H     Me   Me    166-167    181    Me    H       CF.sub.3                              H     Me   Me    164-165    182    H     H       F    H     H    H     168.6-169.2    183    H     H       CN   H     H    H     176.4-176.8    184    H     H       Cl   H     H    H     167.4-168.3    185    H     Cl      F    H     Me   H     99-150.5    186    H     Cl      F    H     Me   Me    68.4-69.8    187    H     Cl      F    H     H    H     171.8-172.6    188    H     F       F    H     Me   Me    114.4-114.9    189    H     H       F    F     H    H     199.8-200.2    190    H     H       F    F     H    Me    179-180.5    191    H     OMe     F    H     H    H     144.7-146    192    H     Me      F    H     H    H     186.3-186.6    193    Me    H       F    F     H    H     222.5-223    194    H     H       F    F     Me   Me    158-159.3    ______________________________________

and are named as follows:

176. 1-{4-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

177. 1-{4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

178. 1-{3-Chloro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

179. 1-{3-Fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

180. 1-{3-Methoxy-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

181. 1-{3-Trifluoromethyl-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

182. 1-{3-Fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

183. 1-{3-Cyano-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

184. 1-{3-Chloro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

185. 1-{3-Fluoro-4-5-(2-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

186. 1-{3-Fluoro-4-5-(2-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-3-dimethylsulfamide.

187. 1-{3-Fluoro-4-5-(2-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

188. 1-{3-Fluoro-4-5-(2-fluorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-3-di-methylsulfamide.

189. 1-{3,5-Difluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

190. 1-{3,5-Difluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

191. 1-{3-Fluoro-4-5-(2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

192. 1-{3-Fluoro-4-5-(2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

193. 1-{3,5-Difluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

194. 1-{3,5-Difluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

IId. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₃═R₂₅ ═R₂₆ ═H; R₁₀ ═represented by formula (A); R₂₀ ═is a grouprepresented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ NR₃₂ R₃₄, are:

    ______________________________________    CPD#  R.sub.12                  R.sub.14                          R.sub.3                               R.sub.22                                    R.sub.32                                          R.sub.34                                               M.Pt. ° C.    ______________________________________    195   H       OMe     H    H    Me    Me   147-148    196   H       OMe     H    F    H     H    133    197   H       OMe     Me   F    H     H    175-176.5    198   H       OMe     Me   F    Me    Me   165.3-166.2    199   H       SMe     H    H    Me    Me   117-118    200   H       SMe     Me   H    Me    Me   161.4-163.2    201   H       NMe.sub.2                          H    F    H     H    193    202   H       OMe     H    CN   H     H    193    203   H       NMe.sub.2                          H    CN   H     H    185    204   H       F       Me   F    H     H    184.8-185.2    205   H       F       Me   F    Me    Me   151-151.4    206   H       F       Me   F    H     Me   128-129    207   H       SMe     Me   F    Me    Me   177.8-178.3    208   H       CF.sub.3                          Me   F    Me    Me   188-189    209   H       cyclo-  H    F    Me    Me   128.6-129.2                  propyl    210   H       CF.sub.3                          Me   F    H     Me   179-179.9    211   H       CF.sub.3                          Me   Cl   H     H    200-201    212   F       F       H    F    H     Me   90-92    213   H       OC.sub.2 H.sub.5                          H    F    Me    Me   158.2-158.7    214   OMe     F       H    F    Me    Me   159-160    215   OMe     F       H    F    H     Me   152.2-157.5    216   H       OC.sub.2 H.sub.5                          H    F    H     H    152.4-153.2    217   Me      OMe     H    F    H     H    157.7-158.3    218   Me      Br      H    F    H     H    162.3-162.9    219   OMe     F       H    F    H     H    101.4-108.5    220   F       OMe     H    F    H     H    168.9-171.5    221   H       Cl      H    F    H     H    190-190.3    ______________________________________

and named as follows:

195. 1-{4-5-(4-Methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

196. 1-{3-Fluoro-4-5-(4-Methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

197. 1-{3-Fluoro-4-5-(4-Methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

198. 1-{3-Fluoro-4-5-(4-Methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

199. 1-{4-5-(4-Methylthiobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethyl-sulfamide.

200. 1-{4-5-(4-Methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

201. 1-{3-Fluoro-4-5-(4-dimethylaminobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

202. 1-{3-Cyano-4-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

203. 1-{3-Cyano-4-5-(4-dimethylaminobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

204. 1-{3-Fluoro-4-5-(4-fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

205. 1-{3-Fluoro-4-5-(4-fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

206. 1-{3-Fluoro-4-5-(4-fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

207. 1-{3-Fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

208. 1-{3-Fluoro-4-5-(4-trifluoromethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

209. 1-{3-Fluoro-4-5-(4-cyclopropylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

210. 1-{3-Fluoro-4-5-(4-trifluoromethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

211. 1-{3-Chloro-4-5-(4-trifluoromethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

212. 1-{3-Fluoro-4-5-(2,4-difluorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

213. 1-{3-Fluoro-4-5-(4-ethoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

214. 1-{3-Fluoro-4-5-(4-fluoro-2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

215. 1-{3-Fluoro-4-5-(4-fluoro-2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methylsulfamide.

216. 1-{3-Fluoro-4-5-(4-ethoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

217. 1-{3-Fluoro-4-5-(4-methoxy-2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

218. 1-{3-Fluoro-4-5-(4-bromo-2-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

219. 1-{3-Fluoro-4-5-(4-fluoro-2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

220. 1-{3-Fluoro-4-5-(2-fluoro-4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

221. 1-{3-Fluoro-4-5-(4-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

IIe. Compounds of formula (I) where R₁ +R₅ ═--(CH₂)₂ --; R₃ ═R₄ ═R₁₂═R₁₃ ═R₁₅ ═R₁₆ ═R₂₃ ═R₂₅ ═R₂₆ ═H; R₁₀ ═is a group represented by formula(A); R₂₀ ═ is a group represented by formula (U); and R₂₄ ═R₃₀ ═NHSO₂NR₃₂ R₃₄, are:

    ______________________________________    CPD#     R.sub.14                     R.sub.22                             R.sub.32                                   R.sub.34                                         M.Pt. ° C.    ______________________________________    222      H       Cl      H     H     115-126    223      CMe     Cl      H     H     112-130    224      H       F       H     H    225      OMe     F       H     H     117.5-172.9    ______________________________________

and are named as follows:

222. 1-{3-Chloro-4-5-benzoyl-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}sulfamide.

223. 1-{3-Chloro-4-5-(4-methoxybenzoyl)-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}sulfamide.

224. 1-{3-Fluoro-4-5-benzoyl-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}sulfamide.

225. 1-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,2-dihydro-3H-pyrrolizin-1-yl!phenyl}sulfamide.

IIIa. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅═R₁₆ ═R₂₂ ═R₂₃ ═R₂₅ ═R₂₆ ═H; R₁₄ ═Cl; R₁₀ ═is a group represented byformula (A); R₂₀ ═ is a group represented by formula (U); and R₂₄ ═R₃₀═NH*C(O)NR₃₂ R₃₃, are:

    ______________________________________    CPD#       R.sub.32 R.sub.33     M.Pt. ° C.    ______________________________________    226        Me       Me           199-201.9    227        H        phenyl       213.5-214.5    228        H        3-Cl-phenyl  219.5-221.5    229        H        CH.sub.2 CO.sub.2 H                                     193.3-194    230        H        (CH.sub.2).sub.2 OH                                     209.6-210.2    231        H        H            214.6-215    ______________________________________

and are named as follows:

226. 1-{1,4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylurea.

227. 1-{1,4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-phenylurea.

228. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(3-chlorophenyl)-urea.

229. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-carboxy-methylurea.

230. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(2-hydroxy-ethyl)-urea.

231. 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}urea.

IIb. Compounds of formula I where R₁ ═Me; R₃ ═R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆═R₂₃ ═R₂₅ ═R₂₆ ═H; R₁₄ ═Me; R₁₀ ═is a group represented by formula (A);R₂₀ ═is a group represented by formula (U); and R₂₄ ═R₃₀ ═NH*C(O)NR₃₂R₃₃, are:

    ______________________________________    CPD#      R.sub.22                      R.sub.32 R.sub.33                                       M.Pt. ° C.    ______________________________________    232       H       Me       Me      167.2-167.7    233       H       H        H       188.4-189.9    234       F       H        (CH.sub.2).sub.2 OH                                       193.7-194.7    ______________________________________

and are named as follows:

232. 1-{4-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylurea.

233. 1-{4-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}urea.

234. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(2-hydroxyethyl)urea.

IV. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆═R₂₃ ═R₂₅ ═R₂₆ ═H; R₁₀ ═is a group represented by formula (A); R₂₀ ═is agroup represented by formula (U); and R₂₄ ═R₃₀ ═NH*C(S)NR₃₂ R₃₃, are:

    ______________________________________    CPD#    R.sub.14                    R.sub.22                            R.sub.32                                  R.sub.33 M.Pt. ° C.    ______________________________________    235     Cl      H       H     CH.sub.2 CH.sub.3                                           80-82    236     Cl      H       H     Me       80-82    237     Cl      H       H     phenyl   158.3-159    238     Cl      H       H     2-Cl-phenyl                                           164.5-166    239     Cl      H       H     4-Cl-phenyl                                           176-177.5    240     Me      F       H     tetrahydro-                                           131.4-132                                  furan-2-yl-                                  methyl    ______________________________________

and are named as follows:

235. 1-{4-5-(4-Chlorobenzoyl)-1,2-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-ethyl-2-thiourea.

236. 1-{4-5-(4-Chlorobenzoyl)-1,2-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methyl-2-thiourea.

237. 1-{4-5-(4-Chlorobenzoyl)-1,2-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-phenyl-2-thiourea.

238. 1-{4-5-(4-Chlorobenzoyl)-1,2-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(2-chlorophenyl)-2-thiourea.

239. 1-{4-5-(4-Chlorobenzoyl)-1,2-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(4-chlorophenyl)-2-thiourea.

240. 1-{3-Fluoro-4-5-(4-methylbenzoyl)-1,2-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(tetra-hydrofuran-2-ylmethyl)-2-thiourea.

V. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆═R₂₃ ═R₂₅ ═R₂₆ ═H; R₁₄ ═Cl; R₁₀ ═is a group represented by formula (A);R₂₀ ═is a group represented by formula (U); and R₂₄ ═R₃₀ NH*C(O)R₃₁,are:

    ______________________________________    CPD#      R.sub.22 R.sub.31      M.Pt. ° C.    ______________________________________    241       H        Me            189-189.9    242       H        CF.sub.3      231.5-234.5    243       H        CH.sub.2 F    180.5-181.7    244       F        Me            184.3-185.1    245       H        morpholino    209.5-210.5    246       H        4-Me piperazino                                     141.8-142.6    247       H        piperazino    >280    248       H        piperazino.HCl                                     >280    249       H        pyrrolidino   217.5-218.4    ______________________________________

and are named as follows:

241. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}acetamide.

242. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}trifluoroacetamide.

243. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}fluoroacetamide.

244. N-{3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}acetamide.

245. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}morpholin-4-ylcarboxamide.

246. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-(4-methyl-piperazin-1-yl)carboxamide.

247. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}piperazin-1-yl-carboxamide.

248. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}piperazin-1-yl-carboxamidehydrochloride.

249. N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}pyrrolidin-1-yl-carboxamide.

VI. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₃ ═R₂₅═R₂₆ ═H; R₁₀ ═is a group represented by formula (A); R₂₀ ═is a grouprepresented by formula (U); and R₂₄ ═R₃₀ ═NHH* are:

    __________________________________________________________________________    CPD# R.sub.3            R.sub.12                R.sub.14                    R.sub.22                        R.sub.30     M.Pt. ° C.    __________________________________________________________________________    250  Me H   Cl  H   NH.sub.2     142.8-145.5    251  Me H   SMe F   NH.sub.2     199.1-199.7    252  H  H   OMe F   NH.sub.2     146.4-147.7    253  H  H   Me  F   NH.sub.2     142.4-143    254  H  H   H   F   NH.sub.2     130.3-131.2    255  Me Me  Me  CN  NH.sub.2     179.8-181.9    256  Me Me  Me  Cl  NH.sub.2     120-121.5    257  Me H   H   F   NHC(O)CH(NH.sub.2)CH(Me).sub.2 (S)                                     130.6-131.5    258  Me H   Me  Cl  NH.sub.2    259  Me H   CF.sub.3                    Cl  NH.sub.2     140-140.8    260  H  Cl  H   F   NH.sub.2     97.9-99    261  H  OMe H   F   NH.sub.2     131.4-132.6    262  Me Me  Me  Cl  NH H*═COCH.sub.3                                     153-155    __________________________________________________________________________

and are named as follows:

250. 4- 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline.

251. 3-Fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline.

252. 3-Fluoro-4-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline.

253. 3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline.

254. 3-Fluoro-4- 5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!aniline.

255. 3-Cyano-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline.

256. 3-Chloro-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline.

257. N-(S)-Valyl-3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!aniline.

258. 3-Chloro-4-5-(4-methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline, m/e=352(M+H).

259. 3-Chloro-4-5-(4-trifluoromethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline.

260. 3-Fluoro-4-5-(2-chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline.

261. 3-Fluoro-4-5-(2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline.

262. N-{3-Chloro-4-5-(2,4-dimethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-acetamide.

VIla. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₅ ═R₁₆ ═H;R,₁₄ ═Cl; R₁₀ ═is a group represented by formula (A); R₂₀ ═is a grouprepresented by formula (V); and R₃₀ ═NH*SO₂ R₃₁, are:

    ______________________________________    CPD#     R.sub.13 R.sub.22                              R.sub.31 M.Pt. ° C.    ______________________________________    263      H        H       Me       191    264      H        H       Me Na.sup.+                                       >280    265      H        H       Me HCl   199-200    266      H        H       CH.sub.2 CH.sub.3                                       181-182    267      H        H       (CH.sub.2).sub.2 OH                                       160-161    268      Cl       H       Me       161.7-162.3    269      Cl       H       CH.sub.2 CH.sub.3                                       67.8-78.8    270      Cl       H       2-thienyl                                       111-114    ______________________________________

and are named as follows:

263. N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

264. N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamidesodium salt.

265. N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamidehydrochloride.

266. N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-ethanesulfonamide.

267. N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-2-(hydroxy)ethanesulfonamide.

268. N-{2-5-(3,4-Dichlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

269. N-{2-5-(3,4-Dichlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-ethanesulfonamide.

270. N-{2-5-(3,4-Dichlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-thiophen-2-ylsulfonamide.

VIIb. Compounds of formula I where R₁ ═Me; R₅ ═R₁₃ ═R₁₅ ═R₁₆ ═H; R₁₄═Me; R₁₀ ═is a group represented by formula (A); R₂₀ ═is a grouprepresented by formula (V); and R₃₀ ═NH*SO₂ R₃₁, are:

    ______________________________________    CPD#   R.sub.3                 R.sub.4                        R.sub.12                             R.sub.22                                   R.sub.31 M.Pt. ° C.    ______________________________________    271    H     H      H    H     Me       158.7-159.5    272    H     H      H    H     (CH.sub.2).sub.2 OH.HCl                                            129    273    Me    H      H    H     Me       179-180    274    Me    H      H    H     CH.sub.2 CH.sub.3                                            56    275    Me    H      H    H     CH(CH.sub.3).sub.2                                            73    276    H     H      H    3-Cl  Me       188.2-190    277    H     H      Me   H     Me.HCl   81-83.5    278    H     Cl     H    H     Me       142.5-142.9    ______________________________________

and are named as follows:

271. N-{2-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}methane-sulfonamide.

272. N-{2-5-(4-Methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-2-(hydroxy)-ethanesulfonamidehydrochloride.

273. N-{2-5-(4-Methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}methane-sulfonamide.

274. N-{2-5-(4-Methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}ethane-sulfonamide.

275. N-{2-5-(4-Methylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-(2-propane)sulfonamide.

276. N-{3-Chloro-2-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

277. N-{2-5-(2,4-Dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamidehydrochloride salt.

278. N-{2-5-(4-Methylbenzoyl)-1-methyl-4-chloro-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

VIIc. Compounds of formula I where R₁ ═Me; R4═R5═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆ ═H;R₁₀ ═is a group represented by formula (A); R₂₀ ═is a group representedby formula (V); and R₃₀ ═NH*SO2R₃₁, are:

    ______________________________________    CPD#   R.sub.3                  R.sub.14                          R.sub.22                                R.sub.31  M.Pt. ° C.    ______________________________________    279    Me     H       H     Me.HCl    204-206    280    Me     H       H     CH.sub.2 CH.sub.3                                          117-118    281    Me     H       H     (CH.sub.2).sub.2 OH.HCl                                          151.5-153    282    Me     SMe     H     CH.sub.2 CH.sub.3                                          210-215    283    Me     SMe     H     Me        175    284    Me     OMe     3-Cl  Me        178-180    285    Me     OMe     H     CH.sub.2 CH.sub.3                                          53.8-64.7    286    Me     F       H     CH.sub.2 CH.sub.3                                          145.5-146.2    287    Me     F       H     Me        166.1-167.2    288    H      OMe     H     Me        141-142    289    Me     OMe     H     Me        149.4-150.2    ______________________________________

and are named as:

279. N-{2-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}methanesulfonamidehydrochloride.

280. N-{2-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}ethanesulfonamide.

281. N-{2-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-2-(hydroxy)-ethanesulfonamide.

282. N-{2-5-(4-Methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-ethanesulfonamide.

283. N-{2-5-(4-Methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

284. N-{3-Chloro-2-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

285. N-{2-5-(4-Methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}ethane-sulfonamide.

286. N-{2-5-(4-Fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}ethane-sulfonamide.

287. N-{2-5-(4-Fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

288. N-{2-5-(4-Methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

289. N-{2-5-(4-Methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

VIII. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R13═R₁₅ ═R₁₆ ═H; R₁₀═is a group represented by formula (A); R₂ ═is a group represented byformula (V); and R₃₀ ═NH*SO₂ NR₃₂ R₃₄, are:

    ______________________________________    CPD#  R.sub.12                 R.sub.14                        R.sub.3                             R.sub.22                                  R.sub.32                                        R.sub.34                                               M.Pt. ° C.    ______________________________________    290   H      Cl     Me   H    Me    Me     154-155.9    291   H      Cl     Me   H    H     H      170-171    292   H      Me     H    H    Me    Me     135-136.5    293   H      Me     H    H    H     H      168.8-169.1    294   H      H      Me   H    Me    Me     146-146.6    295   H      H      Me   H    H     H      162-163    296   H      SMe    Me   H    Me    Me     154.9-159.5    297   H      OMe    Me   3-Cl H     H      179.8-180.2    298   H      Cl     Me   H    H     Me     175.5-176.1    299   H      Cl     Me   H    H     CH.sub.2 CH.sub.3                                               167.3-168.1    300   H      Me     H    H    H     CH.sub.2 CH.sub.3                                               162-163.7    301   H      SMe    Me   H    H     H      175.3-175.7    302   H      F      Me   H    Me    Me     117.3-117.8    303   H      Me     H    H    H     Me     60.3-61.3    304   H      F      Me   H    H     Me     137-142.2    305   H      F      Me   H    H     CH.sub.2 CH.sub.3                                               163-163.5    306   H      OMe    H    H    H     H      179.8-180.2    307   Me     Me     H    H    H     Me     124-130    ______________________________________

and are named as follows:

290. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-di-sulfamide.

291. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}sulfamide.

292. 1-{2-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-dimethyl-sulfamide.

293. 1-{2-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}sulfamide.

294. 1-{2-5-Benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-dimethylsulfamide.

295. 1-{2-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}sulfamide.

296. 1-{2-5-(4-Methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-di-methylsulfamide.

297. 1-{3-Chloro-2-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-dimethylsulfamide.

298. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methyl-sulfamide.

299. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-ethyl-sulfamide.

300. 1-{2-5-(4-Chlorobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-ethylsulfamide.

301. 1-{2-5-(4-Methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}sulfamide.

302. 1-{2-5-(4-Fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-di-methylsulfamide.

303. 1-{2-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methylsulfamide.

304. 1-{2-5-(4-Fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methyl-sulfamide.

305. 1-{2-5-(4-Fluorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-ethyl-sulfamide.

306. 1-{2-5-(4-Methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}sulfamide.

307. 1-{2-5-(2,4-Dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methyl-sulfamide.

IX. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆═R₂₂ ═H; R₁₄ ═Cl; R₁₀ ═is a group represented by formula (A); R₂₀ ═is agroup represented by formula (V); and R₃₀ ═NH*C(O)NR₃₂ R₃₃, are:

    ______________________________________    CPD#       R.sub.32 R.sub.33     M.Pt. ° C.    ______________________________________    308        Me       Me           227-230    309        H        Me           234-235.5    310        H        (CH.sub.2).sub.2 Cl                                     181.8-182.9    311        H        phenyl       194.5-195.2    312        H        3-Cl-phenyl  167.5-168.2    313        H        2-Cl-phenyl  186-188    ______________________________________

and are named as follows:

308. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-di-methylurea.

309. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methylurea.

310. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(2-chloro-ethyl)urea.

311. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-phenylurea.

312. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(3-chlorophenyl)urea.

313. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(2-chlorophenyl)urea.

X. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₂═H; R₁₀ ═is a group represented by formula (A); R₂₀ ═is a grouprepresented by formula (V); and R₃₀ ═NH*C(S)NR₃₂ R₃₃, are:

    ______________________________________    CPD#  R.sub.3                 R.sub.14                        R.sub.22                             R.sub.32                                  R.sub.33   M.Pt. ° C.    ______________________________________    314   Me     Cl     H    H    CH.sub.2 CH.sub.3                                             139-142    315   Me     Cl     H    H    Me         135    316   Me     Cl     H    H    phenyl     154.2-155.5    317   Me     Cl     H    H    cyclohexyl 146-150    318   Me     Cl     H    H    (CH.sub.2).sub.2 OMe                                             136.1-137.9    319   Me     Cl     H    H    tetrahydro-                                             130.6-133.1                                  furan-2-ylmethyl    320   Me     Cl     H    H    CH.sub.2 CO.sub.2 Me                                             155-156.5    321   Me     Cl     H    H    cyclopropyl                                             110-122.5    322   Me     Cl     H    H    (CH.sub.2).sub.2 -morpholine                                             84-98    323   Me     Cl     H    H    phenyl HCl.Salt                                             172-174    324   Me     Cl     H    H    4-Cl-phenyl                                             157.8-158.5    325   Me     Cl     H    H    3-Cl-phenyl                                             157.5-159    326   Me     Cl     H    H    4-SMe-phenyl                                             149-150    327   H      Me     Cl   H    (CH.sub.2).sub.2 OMe                                             172.4-174.2    328   H      Me     Cl   H    tetrahydro-                                             150.1-150.8                                  furan-2-ylmethyl    ______________________________________

and are named as follows:

314. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-ethyl-2-thiourea.

315. 1-{2-5-(4-Chlorobenzoyl)-1,-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methyl-2-thiourea.

316. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-phenyl-2-thiourea.

317. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-cyclohexyl-2-thiourea.

318. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(2-methoxy-ethyl)-2-thiourea.

319. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(tetrahydro-furan-2-ylmethyl)-2-thiourea.

320. 1-{2-5-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(methoxy-carbonyl)methyl!-2-thiourea.

321. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-cyclopropyl-2-thiourea.

322. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-2-(morpho-lin-4-yl)ethyl!-2-thiourea.

323. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-phenyl-2-thioureahydrochloride.

324. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(4-chloro-phenyl)-2-thiourea.

325. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(3-chloro-phenyl)-2-thiourea.

326. 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(4-methyl-thiophenyl)-2-thiourea.

327. 1-{3-Chloro-2-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(2-methoxyethyl)-2-thiourea.

328. 1-{3-Chloro-2-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-(tetra-hydrofuran-2-ylmethyl)-2-thiourea.

XI. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆═R₂₂ ═H; R₁₄ ═Cl; R₁₀ ═is a group represented by formula (A); R₂₀ ═is agroup represented by formula (V); and R₃₀ ═NH*C(O)R₃₁, are:

    ______________________________________    CPD#       R.sub.31       M.Pt. ° C.    ______________________________________    329        Me             194-195    330        H              166.6-167.7    331        CH(NH.sub.2)CH.sub.3.2HCl                              129-210 chiral (R)    332        morpholino     243-244    ______________________________________

and are named as follows:

329. N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}acetamide.

330. N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}formamide.

331. (R)-N-{2- 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-alaninamide.

332. N-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!-pyridin-5-yl}morpholin-4-ylcarboxamide.

XII. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₂ ═H;R₁₀ ═is a group represented by formula (A); R₂₀ ═is a group representedby formula (V); and R₃₀ ═NHH* are:

    ______________________________________    CPD#      R.sub.3  R.sub.12 R.sub.14                                       M.Pt. ° C.    ______________________________________    333       Me       H        Cl     133.1-133.6    334       Me       H        SMe    152.6-153.7    335       H        Me       Me     238.9-240.2    ______________________________________

and are named as:

333. {2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine.

334. {2-5-(4-Methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine.

335. {2-5-(2,4-Dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine.

Miscellaneous compounds:

I. Compounds of formula I where R₁ ═R₃ ═Me; R₄ ═R₅ ═R₁₃ ═R₂₂ ═H; R₂₀ ═isa group represented by formula (V); and R₂₄ ═R₃₀ ═NHSO₂ R₃₁, are:

    ______________________________________    CPD#      R.sub.10   R.sub.31     M.Pt. ° C.    ______________________________________    336       2-thienyl  CH.sub.2 CH.sub.3.HCl                                      166-167    337       2-thienyl  Me.HCl       168-170.5    ______________________________________

and are named as follows:

336. N-{2-5-Thenoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}ethanesulfonamidehydrochloride.

337. N-{2-5-Thenoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}methanesulfonamidehydrochloride.

II. Compound of formula () where R₁ ═Me; R₃ ═R₄ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₄═R₂₅ ═R₂₆ ═H; R₁₄ ═Me; R₁₀ ═is a group represented by formula (A); R₂₀═is a group represented by formula (U); and R₂₃ ═R₃₀ ═NH*SO₂ R₃₁, is:

    ______________________________________    CPD#       R.sub.5  R.sub.22 R.sub.31    ______________________________________    338        H        H        Me      Foam    ______________________________________

and is named as follows:

338. N-{3-5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

III. Compounds of formula I where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₂₃ ═R₂₅ ═R₂₆ ═H;R₂₀ ═is a group represented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ R₃₁,are:

    ______________________________________    CPD#     R.sub.10  R.sub.3                              R.sub.22                                    R.sub.31                                          M.Pt. ° C.    ______________________________________    339      2-thienyl H      H     Me    142-143    340      2-thienyl Me     F     Me    169-170    341      3-pyridyl Me     H     Me    130-132    ______________________________________

and are named as follows:

339. N-{4-5-(2-thenoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

340. N-{3-Fluoro-4-5-(2-thenoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

341. N-{4-5-(2-Nicotinyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

IV. Compounds of formula(I) where R₁ ═Me; R₄ ═R₅ ═R₁₃ ═R₂₃ ═R₂₅ ═R₂₆ ═H;R₂₀ ═is a group represented by formula (U); and R₂₄ ═R₃₀ ═NH*SO₂ NR₃₂R₃₄, is:

    ______________________________________    CFD#  R.sub.10  R.sub.3                           R.sub.22                                 R.sub.32                                       R.sub.34                                             M.Pt. ° C.    ______________________________________    342   2-thienyl Me     F     H     H     204-205    ______________________________________

and is named as follows:

342. 1-{3-Fluoro-4-5-(2-thenoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

V. Compounds of formula I where R₄ ═R₅ ═R₁₂ ═R₁₃ ═R₁₅ ═R₁₆ ═R₂₂ ═R₂₃═R₂₅ ═R₂₆ ═H; R₁₀ ═is a group represented by formula (A); R₂₀ ═is agroup represented by formula (U); and R₂₄ ═R₃₀ are:

    ______________________________________    CPD#    R.sub.1                   R.sub.3                          R.sub.14                                R.sub.30  M.Pt    ______________________________________    343     Me     Me     Cl    OH    344     Me     Me     Cl    OSO.sub.2 NMe.sub.2    345     H      H      SMe   NHSO.sub.2 Me                                          188.7-189    ______________________________________

and are named as follows:

343. 4-{5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl}phenol,m/e=340(M+).

344. 1-N,N-dimethylaminosulfonyloxy-4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!benzene,m/e=446(M+).

345. N-{1-5-(4-Methylthiobenzoyl)-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

PREFERRED COMPOUNDS

Preferred compounds of this invention are those where:

(1) R₁, R₃, R₄, and R₅ are independently H or alkyl; more preferably Hor Me; most preferably R₁ is Me; R₃ is H or Me; and R₄ and R₅ are H;

(2) R₁₀ is a group represented by formula (A);

(3) R₁₂ and R₁₆ are independently H, alkyl, hydroxy, alkyloxy, cyano, orhalo; more preferably H, Me, OH, OMe, F, or Cl; most preferably H, Me,or OMe;

(4) R₁₃ is H or alkyl; more preferably H or Me; most preferably H;

(5) R₁₄ is H, halo, alkyl, dialkylamino, alkoxy, alkylthio, or cyano;more preferably H, Me, OMe, F, Cl, NMe₂, or SMe; most preferably H, F,Cl, Me, or OMe;

(6) R₁₅ is H or halo; more preferably H or Cl; most preferably H;

(7) R₂₀ is a group represented by formula (U) or (V); preferably (U);

(8) where R₂₀ is a group represented by formula (U):

R₂₂ is H, halo, alkyl, cyano, or --CF₃ ; more preferably H, F, Cl, orCN; most preferably

F, Cl, or CN;

R₂₃ and R₂₅ are H;

R₂₄ is R₃₀ ; and

R₂₆ is H, alkyl, or halo; more preferably H, Me, F, or Cl; mostpreferably H or F;

(9) where R₂₀ is a group represented by the formula (V):

R₂₂ is preferably meta to R₃₀ and is preferably H, F, Cl, or cyano; morepreferably H, F, or Cl; most preferably H;

(10) R₃₀ is --NHH*, --NH*C(S)R₃₂ R₃₃, --NH*SO₂ R₃₁, or --NH*SO₂ NR₃₂ R₃₄; more preferably --NHH*, --NH*SO₂ R₃₁, or --NH*SO₂ NR₃₂ R₃₄ ; mostpreferably --NH*SO₂ R₃₁ or --NH*SO₂ NR₃₂ R₃₄

(11) R₃₁ is alkyl, 2-hydroxyethyl, 2,3-dihydroxypropyl, or --(CH₂)_(n)R₃₅ where n is 2 or 3 and R₃₅ is OMe, cycloamino, --NMe₂, or --CO₂ R₂₇where R₂₇ is alkyl; more preferably Me or 2-hydroxyethyl;

(12) R₃₂ is H or Me; more preferably H;

(13) R₃₄ is H, Me, 2-hydroxyethyl, or acetyl; more preferably H or Me;most preferably H; and pharmaceutically acceptable salts thereof.

A number of different substituent preferences have been given in thelist above, and following any of these substituent preferences resultsin a compound of this invention that is more preferred than one in whichthe particular substituent preference is not followed. However, thesesubstituent preferences are generally independent, although somepreferences are mutually exclusive, and following more than one of thesubstituent preferences results in a more preferred compound than one inwhich fewer of the substituent preferences are followed. Thus,particularly preferred compounds of this invention are those in which(to the extent possible) most of the above preferences are followed.

Exemplary particularly preferred compounds are:

N-{3-Cyano-4-5-(4chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

N-{3-Fluoro-4- 5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

N-{3-Fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

N-{3-Fluoro-4-5-(2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide.

N-{3-Fluoro-4-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide.

1-{3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

1-{3-Cyano-4-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-sulfamide.

1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-methyl-2-thiourea

N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

N-{3-Chloro-2--5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}methanesulfonamide.

1-{2--5-(4-Methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}sulfamide.

{2-5-(4-Thiomethylbenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine.

4- 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenol.

N-{2- 5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

1-{3-Fluoro-4- 5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-phenyl}-sulfamide.

N-{2-5-(4-Methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

N-{3,5-Difluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

N-{3-Fluoro-4-5-(2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

N-{3-Fluoro-4-5-(2-methyl-4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-phenyl}-2-(hydroxy)ethanesulfonamide.

N-{3-Fluoro-4-5-(2-chloro-4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

N-{3-Fluoro-4-5-(2-methoxy-4-methyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

N-{3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

GENERAL SYNTHETIC SCHEME

Compounds of this invention can be made by the methods depicted in thereaction schemes shown below.

The starting materials and reagents used in preparing these compoundsare either available from commercial suppliers such as Aldrich ChemicalCo., or are prepared by methods known to those skilled in the artfollowing procedures set forth in references such as Fieser and Fieser'sReagents for Organic Synthesis, Volumes 1-15 (John Wiley and Sons,1991); Rodd's Chemistry of Carbon Compounds, Volumes 1-5 andSupplementals (Elsevier Science Publishers, 1989); and OrganicReactions, Volumes 1-40 (John Wiley and Sons, 1991). These schemes aremerely illustrative of some methods by which the compounds of thisinvention can be synthesized, and various modifications to these schemescan be made and will be suggested to one skilled in the art havingreferred to this disclosure.

The starting materials and the intermediates of the reaction may beisolated and purified if desired using conventional techniques,including but not limited to filtration, distillation, crystallization,chromatography and the like. Such materials may be characterized usingconventional means, including physical constants and spectral data.

Unless specified to the contrary, the reactions described herein takeplace at atmospheric pressure over a temperature range from about -78°C. to about 150° C., more preferably from about 0° C. to about 125° C.and most preferably at about room (or ambient) temperature, e.g., about20° C.

In general compounds of formula I are prepared by modification of5-aroylpyrrol-2-ylmethylanilines ("anilines") or5-aroylpyrrol-2-ylmethylpyridinamines ("pyridinamines"). These anilinesor pyridinamines, which will sometimes be referred to later as compoundsof formula Ia, are compounds of formula I where R₃₀ is --NH_(2;) so theyare both compounds of this invention and are also intermediates tofurther compounds of this invention.

For convenience in the synthetic schemes following, R₂₀ (with theexception of the R₃₀ substituent thereon), will be denoted by --Q--. Theuse of --Q--R₃₀ to denote R₂₀ does not imply that R₂₀ is substitutedonly with R₃₀ ; R₂₀ may contain any other substituents within the scopedescribed in the Summary of the Invention (or as specifically limited ina particular reaction sequence).

Schemes A, B, C and D describe alternative methods to generate thecompounds of formula

Scheme A

The aniline/pyridinamine of formula Ia can be prepared from apyrrole-2-acetate 2 by the method shown in Scheme A. ##STR9##

In Step 1, a 5-aroylpyrrole-2-acetate 3 is prepared by acylating apyrrole-2-acetate 2, where R₁ is not hydrogen and Z is alkyl(particularly Me or ethyl) with an acylating agent of formula 1, whereR₁₀ is as defined in the Summary of the Invention (except that R₁₄ isnot an amino or alkylamino group) and L is a leaving group underacylating conditions such as halo (particularly Cl), dialkylamino(particularly -NMe2), or cycloamino (particularly morpholino)!. Suitablesolvents for the reaction are halogenated and aromatic hydrocarbons(e.g. dichloroethane, xylenes and the like). When L is halo, thereaction proceeds on heating; when L is dialkylamino or cycloamino, thereaction proceeds in the presence of an acid halide such as phosphorusoxychloride, thionyl chloride, phosgene, oxalyl chloride, and the like(a Vilsmeier-Haack reaction).

In general, the compounds of formula 1, the pyrrole-2-acetates 2 and the5-aroylpyrrole-2-acetates 3 are known to or can readily be synthesizedby those of ordinary skill in the art. For example, synthesis of apyrrole-2-acetate 2, where R₁ and R₃ are methyl is described by StahleyG. P., Marlett E. M., and Nelson G. E., J. Org. Chem.; 48:4423 (1983)and where R₁ is hydrogen and R₅ is H or alkyl is described by SchloemerG. C., et. al., J. Org. Chem.; 59, 5230 (1994).

Also, a pyrrole-2-acetate 2 where R₅ is alkyl can be prepared byreacting a pyrrole-2-acetate 2 where R₅ is hydrogen, with an alkylatingagent R₅ L where L is a leaving group under alkylating conditions, suchas halo, methanesulfonate, p-toluenesulfonate and the like. The reactionis carried out in the presence of a base (e.g., cesium carbonate, sodiumhydride, or potassium carbonate) in a suitable polar aprotic organicsolvent such as ether, THF, dioxane, DMF and the like. However, it ispreferable to introduce R₅ as the alkyl group, in Step (2) of thesynthesis as described below.

The 5-aroylpyrrole-2-acetates 3, where R₁ is alkyl and R₃ is methylthioor where R₁ and R₅ together form --(CH₂)₂ --, and their synthesis aredescribed in Muchowski, J. M.; Galeazzi, E., et al., J. Med. Chem.32,1202-1207, (1989).

Certain 5-aroylpyrrole-2-acetates 3 are also commercially available. Forexample the sodium salts of zomepirac,5-(4-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetate and tolmetin,5-(4-methyl-benzoyl)-1-methylpyrrole-2-acetate are available from SigmaChemical Company.

If a compound of formula 3 is obtained as an acid or salt, it isconverted to an alkyl (preferably Me or ethyl) or an allyl ester priorto Step 2. The allyl ester is preferred when --Q-- in compound 5contains an electron withdrawing group such as a halo group meta to thenitro group or a base sensitive group such as a cyano group as one ofthe substituents. The alkyl or allyl ester is prepared by reacting thealkali metal salt of compound 3 with an alkylating agent such as analkyl (preferably Me or ethyl) or allyl halide (e.g., Cl or Br).Suitable solvents for the reaction are polar aprotic organic solvents.If compound 3 is obtained as an alkyl ester (e.g., Z═Me or ethyl) butthe allyl ester is preferred, the alkyl ester is converted to thecorresponding allyl ester by heating it in an excess of allyl alcohol inthe presence of a suitable basic catalyst such as titanium isopropoxide.

In Step 2, a 2-(5-aroylpyrrol-2-yl)-2-(nitrophenyl/nitropyridyl)acetate5 is prepared by nucleophilic substitution of X" in a nitro compound offormula 4, where X" is a leaving group under arylation conditions (e.g.,Cl, F, --OSO₂ Me, --OSO₂ CF₃, and the like) by a5-aroylpyrrole-2-acetate 3. The reaction is carried out in the presenceof a strong base (e.g., sodium or potassium hydride, lithiumdiisopropylamide and the like) under an inert atmosphere (e.g., argon ornitrogen). Suitable solvents are aprotic organic solvents (e.g.,tetrahydrofuran, dimethylformamide, and the like). Additionally, acompound of formula 5 where R₅ is alkyl can be prepared from a compoundof formula 3 where R₅ is hydrogen, by carrying out the above arylationprocedure in the presence of an alkylating agent R₅ L, where L is aleaving group under alkylating condition.

Compounds of formula 4 are commercially available or can be synthesizedby one of ordinary skill in the art.

In Step 3, a nitrobenzene/nitropyridine 6 is prepared by hydrolysis anddecarboxylation of the ester group in a compound of formula 5. Ifcompound 5 is the alkyl ester, the hydrolysis/decarboxylation proceedson heating, in the presence of an aqueous solution of a suitable base(e.g., LiOH, NaOH and the like) and in a suitable organic solvent suchas methanol methoxyethanol DMF, THF, or mixtures thereof (preferably ahigh boiling solvent such as methoxyethanol or DMF). If thedecarboxylation does not occur during the hydrolysis, it is effected byacidifying the reaction mixture with an aqueous acid such as HCl to givethe free acid, which undergoes decarboxylation either at ambienttemperature or upon heating in a high boiling organic solvent.

If compound 5 is the allyl ester, the deprotection reaction proceeds atambient temperature, in the presence of a palladium catalyst (e.g.,tetrakis(triphenylphosphine) palladium), an allyl scavenger (e.g.,morpholine or pyrrolidine) and under an inert atmosphere. Suitablesolvents for the reaction are polar organic solvents (e.g., THF,dioxane, or DMF).

In Step 4, an aniline/pyridinamine of formula Ia is prepared by reducingthe nitro group of nitrobenzene/nitropyridine 6 to an amino group.Suitable nitro group reducing conditions include iron metal withammonium chloride in ethanol/water, nickel boride in acidic methanol orcatalytic hydrogenation using a platinum or palladium catalyst (e.g.,PtO₂ or Pd/C) in an alcoholic solvent (e.g., methanol or ethanol,preferably ethanol).

Alternatively, a compound of formula Ia can be prepared from an alkylester of compound 5 by carrying out the reduction of the nitro group tothe amino group, followed by the hydrolysis and decarboxylation of theester group in the resulting aniline/pyridinamine-acetate of formula 7,utilizing the reaction conditions described in Steps 4 and 3 above. Ingeneral this alternative route for the synthesis of compounds of formulaIa is preferred over the hydrolysis/decarboxylation, followed byreduction sequence described in steps 3 and 4 above when 5 is the alkylester.

The synthesis of a (5-aroylpyrrol-2-ylmethyl)aniline and a2-(5-aroylpyrrol-2-ylmethyl)-pyridin-5-yl}amine utilizing the reactionconditions described in Scheme A is given in Examples 1-6.

Scheme B ##STR10##

The aniline/pyridinamine of formula Ia can also be prepared from apyrrole-2-acetate 2 by the method shown in Scheme B.

In Step 1, a 2-pyrrole-2-(nitrophenyl/nitropyridyl)acetate 8 is preparedby proceeding as in Step 2 of Scheme A but substituting apyrrole-2-acetate 2 for a 5-aroylpyrrole-2-acetate 3.

In Step 2, a (pyrrol-2-ylmethyl)nitrobenzene/nitropyridine 9 is preparedby proceeding as in Step 3 of Scheme A but substituting a compound offormula 8 for a compound of formula 5.

In Step 3, a 2-(5-aroylpyrrol-2-ylmethyl)nitrobenzene/nitropyridine 6 isprepared from the compound of formula 9 by 5-arylation, utilizing thereaction conditions described in Step 1 of Scheme A.

In Step 4, an aniline/pyridinamine Ia is prepared by reduction of thenitro group in compound 6, utilizing the reaction conditions describedin Step 4 of Scheme A Although Scheme B is generally suitable forsynthesis of compounds of formula I that are within the scope of thisinvention, it is particularly suitable for the preparation of compoundsof formula I where R₁₄ is an amino or alkylamino group. A detaileddescription of the synthesis of a compound of formula Ia by this methodis given in Example 7.

Scheme C

The aniline/pyridinamine of formula Ia where R₁ is H or alkyl and R₅ ishydrogen, can also be prepared starting from a pyrrole as shown inScheme C. ##STR11##

In Step 1, a 2-(nitroaroyl)pyrrole 12 is prepared by proceeding as inStep 1 of Scheme A but substituting an acylating agent of formula 10 anda pyrrole of formula 11 for the compounds of formula 1 and 2respectively.

In Step 2, a (pyrrol-2-ylmethyl)nitrobenzene/nitropyridine 13 isprepared by reduction of the ketone group in compound 12 with a reducingagent selective for the ketone group, such as sodium cyanoborohydride inpresence of a catalyst such as zinc iodide. Suitable solvents for thisreaction include dihalogenated solvents (e.g., dichloromethane ordichloroethane).

A compound of formula Ia is then prepared from the compound of formula13 by 5-acylation, followed by nitro group reduction in steps (3) and(4), utilizing the reaction conditions described in Steps 1 and 4 ofScheme A.

This route is particularly suited for preparing compounds of formula Iwhere R₂₀ is a group represented by the formula (U) in which R₂₃ or R₂₅is R₃₀.

A detailed description of the synthesis of a compound of formula Ia bythis method is given in Example 8.

Scheme D

The aniline/pyridinamine of formula Ia can also be prepared by themethod shown in Scheme D. ##STR12##

In Step 2 of Scheme A but substituting a nitrile of formula 15 for anitro compound of proceeding as in Step 2 of Scheme A but substituting anitrile of formula 15 for a nitro compound of formula 4.

In Step 2, a (5-aroylpyrrol-2-ylmethyl)benzoic/nicotinic acid 17 isprepared by proceeding as in Step 3 of Scheme A but substituting thecompound of formula 16 for a compound of formula 5. The hydrolysis/decarboxylation reaction condition also causes the hydrolysis of thenitrile group.

In step 3, a compound of formula Ia is then prepared from a compound offormula 17, using a Curtius rearrangement reaction. Suitable conditionsare those described in Yamada F., et al.; J. Am Chem. Soc.; 6203, (1974)and Yamada F., et al.; Tetrahedron, 30, 2151 (1974). The preparation ofa compound of formula Ia by this method is described in Example 9.

Schemes E-I describe methods to prepare other compounds of formula Ifrom compounds of formula Ia.

Scheme E

Scheme E describes the synthesis of compounds of formula I where R₃₀ isOH: ##STR13##

A compound of formula I where R₃₀ is --OH can be prepared by convertingan aniline/pyridinamine of formula Ia to a diazonium salt, which uponhydrolysis in an aqueous acid gives the hydroxy group. The diazoniumsalt is prepared by reacting a compound of formula Ia with a nitritesalt (e.g., NaNO₂, KNO₂ and the lie) in an aqueous solvent (e.g., water,aqueous acetic acid, aqueous organic mixtures such as aceticacid/acetone) or an alkyl nitrite such as isoamylnitrite in anon-aqueous solvent such as glacial acetic acid, acetone or a mixturethereof. The conversion of a compound of formula Ia to a compound offormula I where R₂₄ ═R₃₀ is --OH is described in detail in Example 10.

Scheme F

Scheme F describes the synthesis of compounds of formula I where R₃₀ is--NHC(O)R₃₁ : ##STR14##

A compound of formula I where R₃₀ is an amide group can be prepared,either:

(a) by reacting an aniline/pyridinamine of formula Ia with an acylatingreagent R₃₁ COL, where L is a leaving group under acylating conditions,such as a halo (particularly Cl or Br) or imidazolide. Suitable solventsfor the reaction include aprotic polar solvents (e.g., dichloromethane,THF, dioxane and the like.) When an acyl halide is used as the acylatingagent the reaction is carried out in the presence of a non-nucleophilicorganic base (e.g., triethylamine or pyridine, preferably pyridine); or

(b) by heating a compound of formula Ia with an acid anhydride. Suitablesolvents for the reaction are THF, dioxane and the like. Detaileddescriptions of the conversion of a compound of formula Ia to compoundsof Formula I where R₃₁ is --NHC(O)CH₃ or --NHCHO are given in Examples11 and 12.

Scheme G

Scheme G describes the synthesis of compounds of formula where R₃₀ is--NHC(X)NR₃₂ R₃₃ : ##STR15##

A compound of formula I where R₃₀ is a urea/thiourea group can beprepared, either:

(a) by reacting an aniline/pyridinamine of formula Ia with an activatingagent such as carbonyl diimidazole/thiocarbonyl diimidazole, followed bynucleophilic displacement of the imidazole group with a primary orsecondary amine. The reaction occurs at ambient temperature. Suitablesolvents include polar organic solvents (e.g., THF, dioxane and thelike);

(b) by reacting a compound of formula Ia with a carbamoyl/thiocarbamoylhalide. The reaction is carried out in the presence of anon-nucleophilic organic base. Suitable solvents for the reaction aredichloromethane, 1,2-dichloroethane, THF, or pyridine; or

(c) by reacting a compound of formula Ia with anisocyanate/isothiocyanate in an aprotic organic solvent (e.g., benzene,THF, DMF and the like). Detailed descriptions of the conversion of acompound of formula Ia to compounds of formula I where R₃₀ is--NHC(O)NHCH₂ CH₂ OH, --NHC(O)NMe₂, --NHC(O)NHMe, or --NHC(S)NHMe aregiven in Examples 13-16.

Scheme H

Scheme H is used to synthesize compounds of formula I where R₃₀ is--NHSO₂ R₃₁ : ##STR16##

A compound of formula I where R₃₀ is a sulfonamide group can beprepared, either:

(a) by reacting an aniline/pyridinamine of formula Ia with a sulfonylhalide, utilizing the reaction conditions described in method (b) ofScheme G. Sulfonyl halides are commercially available or may be preparedby methods such as those described in (1) Langer, R. F.; Can J. Chem.;61, 1583-1592, (1983); (2) Aveta, R.; et. al.; Gazetta Chimica Italiana,116, 649-652, (1986); (3) King, J. F. and Hillhouse, J. H.; Can. J.Chem.; 54,498, (1976); and (4) Szymonifka, M. J. ane Heck, J. V.; Tet.Lett.; 30, 2869-2872, (1989). Detailed descriptions of the conversion ofa compound of formula Ia to compounds of formula I where R₃₀ is --NHSO₂Me, --NHSO₂ (CH₂)₂ OH, --NHSO₂ CH═CH₂, or --NHSO₂ (CH₂)₂ NMe₂ are givenin Examples 17-20.

(b) by reacting a compound of formula 9 with two equivalents of asulfonyl halide in the presence of a non-nucleophilic organic base togive a bis-sulfonamide. Suitable solvents for the reaction arehalogenated organic solvents (e.g., dichloromethane, dichloroethane,CCl₄ and the like). The resulting bis-sulfonamide is 5-acylated underthe reaction conditions described in Step 1 of Scheme A. Hydrolysis ofone of the sulfonyl groups in presence of an inorganic base (e.g., LiOH,KOH and the like) gives a compound of formula I. Suitable solvents forthe hydrolysis include THF, dioxane, DMF, and the like. A detaileddescription of the conversion of a compound of formula Ia to a compoundof formula I, where R₃₀ is --NHSO₂ Me by this procedure is given inExample 21.

Scheme I

Scheme I was used to prepare compounds of formula I where R₃₀ is --NHSO₂NR₃₂ R_(34:) ##STR17##

A compound of formula I where R₃₀ is a sulfamide group can be prepared,either:

(a) by reacting an aniline/pyridinamine of formula Ia with a sulfamoylhalide, utilizing the reaction conditions described in method (b) ofScheme G. Sulfamoyl halides are commercially available or may beprepared by methods such as those described in Graf, R; German Patent,931225 (1952) and Catt, J. D. and Matler, W. L; J. Org. Chem., 39,566-568, (1974); or

(b) by an amine exchange reaction, in which a dimethyl sulfamide(prepared according to the method described above) is heated with anamine NHR₃₂ R₃₄ in an aromatic hydrocarbon in presence of an excessamount of a non-nucleophilic organic base. Detailed descriptions of theconversion of a compound of formula Ia to a compound of formula I whereR₃₀ is --NHSO₂ NMe₂, --NHSO₂ NH₂, or --NHSO₂ -morpholine are given inExamples 22-24.

Additional Processes

Compounds of formula I and Ia having a group that would be unstableunder the reaction conditions utilized in Schemes A-I can be prepared bythe modification of another group present on a corresponding compound offormula I and Ia, e.g.; compounds of formula I containing a hydroxygroup may be prepared by de-alkylation/benzylation of analkyloxy/benzyloxy substituent; those containing an acid group, byhydrolysis of an ester group; and those containing a cyano, bydisplacement of a bromine atom on the corresponding compounds of formulaI. Similarly, a compound of formula Ia having an alkenyl or alkynylgroup can be prepared by reacting a corresponding compound of formula Iacontaining a bromine or iodine atom with trimethylsilylacetylene underthe Castro-Stephens reaction conditions. A detailed description of theconversion of a benzyloxy group to a hydroxy group; an ester group to anacid and a bromine atom to a cyano group are given in Examples 25-27respectively. Furthermore, a compound of formula I and Ia can preparedby substitution of a group present on a corresponding compound offormula I and Ia, e.g., a compound of formula Ia where R₁₄ is H, oralkylthio may be conveniently prepared by dehalogenation/substitution ofa chlorine atom on a corresponding compound of formula Ia. Theconversion of a compound of formula Ia where R₁₄ is chloro to acorresponding compound of formula Ia where R₁₄ is H or methylthio isdescribed in Examples 28 and 29 respectively.

General Utility

The compounds of the invention are inhibitors of prostaglandin G/HSynthase I and II (COX I and COX II), especially COX II, in vitro, andas such are expected to possess both anti-inflammatory and analgesicproperties in vivo. See, for example, Goodman and Gilmans's "ThePharmacological Basis of Therapeutics", Ninth Edition, McGraw Hill,N.Y., 1996, Chapter 27. The compounds, and compositions containing them,are therefore useful as anti-inflammatory and analgesic agents inmammals, especially humans. They find utility in the treatment ofinflammation and pain caused by diseases such as arthritis, gout, andautoimmune disorders (such as systemic lupus erythematosus, rheumatoidarthritis, and type I diabetes).

As inhibitors of prostaglandin G/H Synthase, the compounds of thisinvention are also expected to be useful in the prevention and treatmentof cancer, in particular colon cancer. It has been shown that COX-2 geneexpression is upregulated in human colorectal cancers and that drugsthat inhibit prostaglandin G/H Synthase are effective in animal modelsof cancer (Eberhart, C. E., et. al.; Gastroenterology, (1994), 107,1183-1188 and Ara, G., and Teicher, B. A., Prostaglandins, Leukotrienesand Essential Fatty Acids, (1996), 54, 3-16). In addition, there isepidemiological evidence that shows a correlation between use of drugsthat inhibit prostaglandin G/H synthase and a reduced risk of developingcolorectal cancer, (Heath, C. W. Jr., et. al.; Cancer, (1994), 74, No.10, 2885-8).

The compounds of this invention are also expected to be useful in theprevention and treatment of Alzheimer's disease. Indomethacin, aninhibitor of prostaglandin G/H synthase, has been shown to inhibit thecognitive decline of Alzheimer's patients, (Rogers, J., et. al.,Neurology, (1993), 43, 1609). Also, the use of drugs which inhibitprostaglandin G/H synthase has been linked epidemiologically with adelayed onset of Alzheimer's disease, (Breitner, J. C. S., et. al.,Neurobiology of Aging, (1995), 16, No. 4, 523 and Neurology, (1994), 44,2073).

Testing

The anti-inflammatory activity of the compounds of this invention may beassayed by measuring the ability of the compound to inhibit COX I andCOX II, especially COX II, in vitro, using a radiometric assay, asdescribed in more detail in Example 31. It may also be assayed by invivo assays such as the Rat Carrageenan Paw, and Rat Air-Pouch assays,as described in more detail in Examples 32 and 33. The analgesicactivity of the compounds of this invention may be assayed by in vivoassays such as the Acetic Acid induced Rat Writhing Assay, and the ratarthritis pain model, as described in more detail in Example 34.

Administration and Pharmaceutical Composition

In general, the compounds of this invention will be administered in atherapeutically effective amount by any of the accepted modes ofadministration for agents that serve similar utilities. The actualamount of the compound of this invention, i.e., the active ingredient,will depend upon numerous factors such as the severity of the disease tobe treated, the age and relative health of the subject, the potency ofthe compound used, the route and form of administration, and otherfactors.

Therapeutically effective amounts of compounds of formula I may rangefrom approximately 0.1-75 mg per Kilogram body weight of the recipientper day; preferably about 5-20 mg/Kg/day. Thus, for administration to a70 Kg person, the dosage range would most preferably be about 350 mg to1.4 g per day.

In general, compounds of this invention will be administered aspharmaceutical compositions by any one of the following routes: oral,systemic (e.g., transdermal, intranasal or by suppository), orparenteral (e.g., intramuscular, intraveneous or subcutaneous)administration. The prefered manner of administration is oral using aconvenient daily dosage regimen which can be adjusted according to thedegree of affliction. Compositions can take the form of tablets, pills,capsules, semisolids, powders, sustained release formulations,solutions, suspensions, elixirs, aerosols, or any other appropriatecompositions and are comprised of, in general, a compound of formula Iin combination with at least one pharmaceutically acceptable excipient.Acceptable excipients are non-toxic, aid administration, and do notadversely affect the therapeutic benefit of the compound of formula I.Such excipient may be any solid, liquid, semi-solid or, in the case ofan aerosol composition, gaseous excipient that is generally available toone of skill in the art.

Solid pharmaceutical excipients include starch, cellulose, talc,glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silicagel, magnesium stearate, sodium stearate, glycerol monostearate, sodiumchloride, dried skim milk and the like. Liquid and semisolid excipientsmay be selected from glycerol, propylene glycol, water, ethanol andvarious oils, including those of petroleum, animal, vegetable orsynthetic origin, e.g., peanut oil, soybean oil, mineral oil, sesameoil, etc. Preferred liquid carriers, particularly for injectablesolutions, include water, saline, aqueous dextrose, and glycols.

Compressed gases may be used to disperse a compound of this invention inaerosol form. Inert gases suitable for this purpose are nitrogen, carbondioxide, etc.

Other suitable pharmaceutical excipients and their formulations aredescribed in Remington's Pharmaceutical Sciences, edited by E. W. Martin(Mack Publishing Company, 18th ed., 1990).

The level of the compound in a formulation can vary within the fullrange employed by those skilled in the art. Typically, the formulationwill contain, on a weight percent (wt %) basis, from about 0.01-99.99 wt% of a compound of formula I based on the total formulation, with thebalance being one or more suitable pharmaceutical excipients.Preferably, the compound is present at a level of about 1-80 wt %.Representative pharmaceutical formulations containing a compound offormula I are described in Example 30.

EXAMPLES

The following preparations and examples are given to enable thoseskilled in the art to more clearly understand and to practice thepresent invention. They should not be considered as limiting the scopeof the invention, but merely as being illustrative and representativethereof.

Example 1 Synthesis of 3-fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline ##STR18##

Ethyl 1,4-dimethylpyrrole-2-acetate (37.0 g, 0.19 mol), benzoyl chloride(54.3 g, 0.38 mol), and triethylamine (52.9 ml, 0.38 mol) were dissolvedin xylenes (750 ml), and the reaction mixture was refluxed for 18 hunder argon. The reaction mixture was cooled to room temperature and thesolvent was removed in vacuo. Purification on a Florisil® column (hexanefollowed by hexane-ethyl acetate, 4:1) gave ethyl5-benzoyl-1,4-dimethylpyrrole-2-acetate (30.45 g, 57%) as a solid.##STR19##

Ethyl 5-benzoyl-1,4-dimethylpyrrole-2-acetate (5.0 g, 17.5 mmol)prepared as in Example 1, Step (a)!, was dissolved in DMF (50 ml) andthe solution was cooled in an ice bath to 0 ° C. under an argonatmosphere. Sodium hydride, 50% /mineral oil, (1.3 g, 27.1 mmol) wasadded, and after 5 min 3,4-difluoronitrobenzene (3.36 g, 21.1 mmol) wasadded to the reaction mixture. After 1 h the reaction mixture was pouredinto 10% HCl/ice and the product was extracted into ethyl acetate. Theorganic phase was washed with water, dried over sodium sulfate, andevaporated to dryness. Purification on a Florisil® column (hexane-ethylacetate, 9:1) gave ethyl2-(5-benzoyl-1,4-di-methylpyrrol-2-yl)-2-(2-fluoro-4-nitrophenyl)acetate(6.22 g, 84%) as a solid. ##STR20##

A mixture of ethyl2-(5-benzoyl-1,4-dimethylpyrrol-2-yl)-2-(2-fluoro-4-nitrophenyl)-acetate(6.0 g, 14.1 mmol) prepared as in Example 1, Step (b)!, nickel boride(8.0 g, 62.4 mmol), hydrochloric acid (50 ml, 1 M) and methanol (150 ml)was heated at reflux for 1 h. The reaction mixture was cooled andfiltered through Celite®. After removing the methanol in vacuo, theresulting aqueous mixture was made basic with ammonium hydroxide, andthe product was extracted into ethyl acetate. The organic layer waswashed with brine and dried over sodium sulfate. Evaporation of theorganic layer gave ethyl2-(5-benzoyl-1,4dimethyl-pyrrol-2-yl)-2-(2-fluoro-4-aminophenyl)acetate(5.3 g, 95%). ##STR21##

Ethyl2-(5-benzoyl-1,4-dimethylpyrrol-2-yl)-2-(2-fluoro-4-aminophenyl)acetate(5.3 g, 13.4 mmol) prepared as in Example 1, Step (c)! and 50% aqueousNaOH (5 ml) were dissolved in a 1:1 mixture of methanol/THF (100 ml),and the reaction mixture was refluxed for 30 min. After removing thesolvents in vacuo, the residue was diluted with water and acidified withconcentrated HCl. The product was extracted into ethyl acetate, and theorganic layer was washed with brine, dried over sodium sulfate, and thesolvent was removed under reduced pressure. The residue was re-dissolvedin DMF (200 ml) and refluxed for 30 min. The reaction mixture wascooled, poured into water/ice, and the product was extracted into ethylacetate. The organic layer was washed with water and dried over sodiumsulfate. Evaporation of the solvent gave 3-fluoro-4-5-benzoyl-1,4-di-methyl-1H-pyrrol-2-ylmethyl!aniline (3.12 g, 69%) as asolid.

Example 2 Synthesis of 4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline ##STR22##

Ethyl 2-(5-benzoyl-1,4-dimethylpyrrol-2-yl)-2-(4-nitrophenyl)acetate(8.2 g, 20.2 mmol) prepared by proceeding as described in Example 1,Steps (a) and (b) ! was dissolved in a 1:1 mixture of methanol (200 ml).An aqueous solution of LiOH (250 mi 0.4 M, 100.9 mmol) was added and themixture was stirred at 60° C. for 2 h. The organic solvents wereevaporated in vacuo, the aqueous residue was acidified with 10% HCl, andthe product was extracted into ethyl acetate. The organic phase waswashed with water, dried over sodium sulfate, and concentrated undervacuum. Purification on a Florisil® column (hexane-ethyl acetate, 4:1)gave 4- 5-benzoyl-1,4dimethyl-1H-pyrrol-2-ylmethyl!-nitrobenzene (6.68g, 99%) as a yellow solid. ##STR23##

To a slurry of 4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!nitrobenzene (3.55 g, 10.6mmol) prepared as in Example 2, Step (a) ! in methanol (170 ml) andhydrochloric acid (50 ml 1 M) was added nickel boride (3.41 g, 26.6mmol), and the mixture was stirred at 75° C. for 15 h. The reactionmixture was cooled, basified with ammonium hydroxide and the product wasextracted into ethyl acetate. The organic phase was washed with waterand dried over sodium sulfate. Evaporation of the solvent gave 4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline (3.11 g, 96%) as apale yellow solid.

Example 3 Synthesis of 4-{1-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl!ethyl}aniline ##STR24##

The methyl ester of zomepirac (6.12 g, 20.0 mmol) and4-fluoronitrobenzene (2.65 ml, 25.0 mmol) were dissolved in DMF (65 ml)and sodium hydride, 60%/in mineral oil (1.68 g, 42 mmol) was added atroom temperature. After 30 min methyl iodide (3.12 ml, 50 mmol) wasadded to the reaction mixture and the stirring was continued for anadditional 15 min. The reaction mixture was poured into a mixture of 1Nsodium bisulfate (20 ml) and ice-water and stirred overnight. Theresulting solid was filtered and washed with water. Recrystallizationfrom ethyl acetate-hexane gave methyl 2-5-(4-chlorobenzoyl)-1,4-di-methylpyrrol-2-yl!-2-(4-nitro-phenyl)-2-methylacetate(7.85 g, 89%) as a solid, mp 180.9-181.7° C.

4-{1- 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl!ethyl}aniline canbe prepared from methyl2-{5-(4-chlorobenzoyl)-1,4-dimethylpyrrol-2-yl)-2-(4-nitrophenyl)-2-methyl-acetateby proceeding as in Example 1, Steps (c) and (d) or Example 2, Steps (a)and (b).

Example 4 Synthesis of 3-chloro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline ##STR25##

The sodium salt of tolmetin (15.0 g, 47.6 mmol) and allyl bromide (4.3ml, 49.9 mmol) were dissolved in DMF (50 ml) and the mixture was stirredat room temperature until the esterification was complete (˜30 h). Thesolvent was removed in vacuo and the residue was partitioned betweenether and water. The organic layer was separated, washed with water, 1 Msodium hydroxide, and brine, and dried over sodium sulfate. Evaporationgave allyl 5-(4-methylbenzoyl)-1-methylpyrrole-2-acetate (11.97 g, 85%)as a solid. ##STR26##

Allyl 5-(4-methylbenzoyl)-1-methylpyrrole-2-acetate (11.83 g, 39.8 mmol)prepared as in Example 4, Step (a)! and 3,4-dichloronitrobenzene (7.64g, 39.8 mmol) were dissolved in dry DMF (50 ml). The reaction mixturewas cooled under nitrogen to 0° C. and sodium hydride powder (2.01 g,83.5 mmol) was added in portions. After stirring at 0° C. for 30 min,the reaction mixture was warmed to room temperature and quenched with 1M HCl. The product was extracted into ether and the organic layer waswashed with water and brine and dried over magnesium sulfate.Evaporation gave allyl 2-(5-(4-methylbenzoyl)-1-methylpyrrol-2-yl!-2-(2-chloro-4-nitrophenyl)-acetate(17.15 g, 98%) as a foam. ##STR27##

Allyl 2-(5-(4-methylbenzoyl)-1-methylpyrrol-2-yl!-2-(2-chloro-4-nitrophenyl)acetate(17.15 g, 39.2 mmol prepared as in Example 4, Step (b)! was dissolved inTHF (100 ml) under nitrogen. Morpholine (34.2 ml, 391.7 mmol) andPd(PPh₃)₄ (45 mg, 0.04 mmol) were added and the reaction mixture, whichdeveloped a white precipitate, was stirred for 20 min. The solvent wasremoved in vacuo and the residue was dissolved in ether. The ether layerwas separated and washed with 1 M sodium bisulfate and brine, and driedover magnesium sulfate. Evaporation gave3-chloro-4-{5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl}nitro-benzene(14.38 g, 99%) as a yellow oil. ##STR28##

3-Chloro-4-{5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}nitrobenzene(14.38 g, 39.0 mmol) prepared as in Example 4, Step (c)! was dissolvedin ethanol (300 ml) and an aqueous solution of ammonium chloride (14.0 gin 150 ml) and iron powder (14.0 g) were added to the solution. Thereaction mixture was refluxed for 30 min, then cooled to roomtemperature and filtered. The filtrate was concentrated, diluted withwater, and extracted with ether and methylene chloride. The organiclayer were combined, washed with brine and dried over sodium sulfate.Evaporation gave3-chloro-4-{5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}aniline(12.09 g, 92%) as a yellow solid.

Example 5 Synthesis of {2-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine##STR29##

A solution of tolmetin methyl ester (30.0 g, 0.11 mol) and2-chloro-5-nitropyridine (21.9 g, 0.138 mol) in DMF (350 ml) was cooledto 4° C. and sodium hydride powder (5.87 g, 0.23 mol) was added inportions. The reaction was stirred for 1.5 h and then poured into a coldaqueous solution of potassium bisulfate (31.0 g in 1500 ml water). Theresulting orange precipitate was filtered, washed with water, driedunder vacuum, and then stirred with ethyl acetate (500 ml). Filtrationgave methyl 2-(5-(4-methylbenzoyl)-1-methylpyrrol-2-yl!-2-(5-nitropyridin-2-yl)-acetate(23 g) as an orange solid, mp 162.5-163.8° C. ##STR30##

Methyl 2-(5-(4-methylbenzoyl)-1-methylpyrrol-2-yl!-2-(5-nitropyridin-2-yl)acetate(34.0 g, 86.4 mmol) prepared as described in Example 5, Step (a)! wasdissolved in a mixture of ethanol/THF (600 ml/200 ml) and subjected tocatalytic hydrogenation over PtO₂ (0.7 g) in a Parr shaker apparatus at30 psi for 4 h. The reaction mixture was filtered through Celite® andthe filtrate was concentrated to dryness. Purification by flashchromatography (hexane-ethyl acetate) gave methyl 2-(5-(4-methylbenzoyl)-1-methyl-pyrrol-2-yl!-2-(5-aminopyridin-2-yl)-acetate(22.0 g, 70%) as a dark orange gum. ##STR31##

To a solution of methyl 2-(5-(4-methylbenzoyl)-1-methylpyrrol-2-yl!-2-(5-amino-pyridin-2-yl)acetate(22.0 g, 60.5 mmol) prepared as in Example 5, Step (b)! in methanol (400ml) was added an aqueous solution of sodium hydroxide (5.8 g, 145.0mmol) in 60 ml water. The dark brown reaction mixture was stirredovernight under argon, then acidified with 3 N HCl to pH 2.5 and stirredan additional 6 h. The reaction mixture was then neutralized with asaturated solution of sodium bicarbonate to pH 7.5. The resulting brownprecipitate was filtered and purified by flash chromatography(hexane-ethyl acetate) to yield a solid. Recrystallization fromhexane-ethyl acetate gave {2-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-pyridin-5-yl}amine(10.2 g, 55%) as a light brown solid, mp 104-106.6° C.

Example 6 Synthesis of 4-5-(2,4-Dimethylbenzoyl)-1-methylpyrrol-2-ylmethyl)aniline ##STR32##

To a suspension of 2,4-dimethylbenzoic acid (10 g, 66.59 mmol) in ethylacetate (100 ml) was added oxalyl chloride (5.81 ml, 66.59 mmol), andthe mixture was slowly heated to 40° C. After 1.5 h, the solvents wereremoved in vacuo, and the product 2,4-dimethylbenzoyl chloride was usedin the next step without purification. ##STR33##

To a solution of 2,4-dimethylbenzoyl chloride (66.59 mmol) prepared asdescribed in Example 6, Step (a)! in cumene (150 ml) was added methyl1-methylpyrrole-2-acetate (8 ml, 55.56 mmol) and lithium carbonate (6.16g , 83.34 mmol), and the reaction mixture was heated to reflux. After1.5 h, the reaction mixture was cooled to ambient temperature and thesolvent was removed in vacuo. Purification by column chromatography(ethyl acetate-hexanes) gave methyl 2-5-(2,4-dimethylbenzoyl)-1-methylpyrrole-2-acetate (4.03 g, 25%), as awaxy solid. ##STR34##

Methyl 2- 5-(2,4-dimethylbenzoyl)-1-methylpyrrole-2-acetate (2.75 g,9.64 mmol) prepared as described in Example 6, Step (b)! and3,4-difluoronitrobenzene (1.28 ml, 11.56 mmol) were dissolved inanhydrous DMF (15 ml) and NaH (486 mg, 20.24 mmol) was added in portionsat 0° C. The reaction mixture was stirred at 0° C. for 2 h, thenquenched with 1N NaHSO₄, and partitioned between ether and 1N NaHSO₄.The organic layer was separated, dried over magnesium sulfate, andconcentrated to dryness. Purification by column chromatography (ethylacetate/hexane) gave methyl 2-5-(2,4-dimethylbenzoyl)-1-methyl-pyrrol-2-yl)-2-(2-fluoro-4-nitrophenyl)acetate(3.56 g, 87%) as a pale yellow oil. ##STR35##

To a solution of methyl 2- 5-(2,4-dimethylbenzoyl)-1-methylpyrrol-2-yl)-2-(2-fluoro-4-nitrophenyl)acetate(3.51 g, 8.27 mmol) prepared as described in Example 6, Step(c)! in 75ml allyl alcohol was added titanium tetraisopropoxide (0.244 ml, 0.827mmol), and the reaction mixture was heated to reflux. After 36 h, thereaction mixture was cooled to room temperature, and partitioned betweenether and water. The organic layer was separated, dried over magnesiumsulfate, and concentrated to dryness to give allyl 2-5-(2,4-dimethylbenzoyl)-1-methylpyrrol-2-yl)-2-(2-fluoro-4-nitrophenyl)-acetate(3.60 g, 97%) as a pale yellow oil. ##STR36##

To a solution of allyl 2- 5-(2,4-dimethylbenzoyl)-1-methylpyrrol-2-yl)-2-(2-fluoro-4-nitrophenyl)acetate(3.6 g, 7.99 mmol) prepared as described in Example 6, Step (d)! inanhydrous THF (40 ml) was added morpholine (6.99 ml, 79.90 mmol) andtetrakis-(triphenylphosphine) palladium (9 mg, 0.008 mmol)). After 1.5h, the solvent was evaporated and the residue was partitioned betweenether and IN NaHSO₄. The organic layer was separated, dried overmagnesium sulfate, and concentrated to dryness. Purification by columnchromatography (ethyl acetate/hexane) gave 4-5-(2,4-dimethylbenzoyl)-1-methyl-pyrrol-2-yl-methyl)nitrobenzene (2.73g, 93%) as a pale yellow oil. ##STR37##

4- 5-(2,4-Dimethylbenzoyl)-1-methylpyrrol-2-ylmethyl)nitrobenzene (923mg, 2.52 mmol) prepared as described in Example 6, Step(e)!, wasdissolved in ethyl acetate (10 ml). 10% Pd/C (92 mg) was added, and thereaction mixture was vigorously stirred under hydrogen atmosphere atambient temperature and atmospheric pressure for 2 h. The mixture wasfiltered through Celite®, and the filtrate was evaporated to dryness togive 4- 5-(2,4-dimethylbenzoyl)-1-methylpyrrol-2-yl-methyl)aniline (718mg, 85%) as pale yellow crystals, mp 107.6-108.5° C.

Example 7 Synthesis of4-{5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}aniline##STR38##

Methyl 1-methylpyrrole-2-acetate (5.0 g, 32.0 mmol) and4-chloronitrobenzene (10.3 g, 65.0 mmol) were dissolved in DMF (30 ml)and the mixture was cooled in an ice bath under argon. Sodium hydride,50% in mineral oil, (3.1 g, 64.0 mmol) was added in portions. Afterstirring for 1 h at room temperature the reaction mixture was pouredinto 1 M HCl/ice and the product was extracted into ethyl acetate. Theorganic extracts were washed with water, dried over sodium sulfate, andconcentrated to dryness. Purification on a Florisil® column (methylenechloride) gave methyl 2-(1-methylpyrrol1-2-yl)-2-(4-nitrophenyl)acetate(4.13 g, 46%) as a solid. ##STR39##

Methyl 2-(1-methylpyrrol-2-yl)-2-(4-nitrophenyl)acetate (3.8 g, 14.0mmol) prepared as in Example 7, Step (a)! was dissolved in a 1:1 mixtureof MeOH-THF (100 ml) and cooled in an ice bath under argon. A solutionof 0.4 M lithium hydroxide (69 ml) was added and the reaction mixturewas stirred at room temperature. After 2 h, the reaction mixture waspoured into 1 M HCl/ice and extracted with ethyl acetate. The organiclayer was washed with water, dried over sodium sulfate and concentratedunder reduced pressure. The solid residue was redissolved in DMF (40 ml)and heated at reflux. After 20 min the reaction mixture was poured intoice/water and extracted with ethyl acetate. The organic layer was washedwith water, dried over sodium sulfate and concentrated to dryness.Purification on a Florisil® column (hexane-ethyl acetate, 9:1) gave4-(1-methylpyrrol-2-yl-methyl)nitrobenzene (2.53 g, 82%) as a solid.##STR40##

4-(1-Methylpyrrol-2-ylmethyl)nitrobenzene (1.2 g, 5.5 mmol) prepared asin Example 7, Step (b)!, 2,4-dimethylbenzoyl chloride (1.6 g, 9.5 mmol),and triethylamine (1.3 ml, 9.3 mmol) were dissolved in xylenes (50 ml),and the reaction mixture was heated at reflux under argon. After 48 h,the reaction mixture was passed through a Florisil® column (hexanefollowed by hexane-ethyl acetate, 95:5) to give4-(5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl)nitrobenzene(0.81 g, 42%) as a solid. ##STR41##

A mixture of4-{5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}nitrobenzene(0.81 g, 2.3 mmol), prepared as in Example 7, Step (c)!, nickel boride(1.6 g), 1 M HCl (30 ml), and methanol (30 ml) was refluxed for 30 min.The reaction mixture was filtered through a pad of Celite® and thefilter cake was washed with ethyl acetate. The filtrate was cooled, madebasic with concentrated ammonium hydroxide, and extracted with ethylacetate. The organic layer was washed with brine, dried over sodiumsulfate and concentrated to give4-{5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}aniline (760mg, 100%) as an oil.

Example 8 Synthesis of3-{5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}aniline ##STR42##

A solution of 1-methylpyrrole (10.0 g, 123.0 mmol), 3-nitrobenzoylchloride (68.47 g, 369 mmol), and triethylamine (17.14 ml, 123 mmol) inxylenes (150 ml) was refluxed for 40 h. Purification of the reactionmixture on a Florisil® column (hexane-acetone, 85:15) gave2-(3-nitrobenzoyl)-1-methylpyrrole (13.0 g, 46%) as a solid. ##STR43##

A mixture of 2-(3-nitrobenzoyl)-1-methylpyrrole (5.0 g, 21.7 mmol)prepared as in Example 8, Step (a)!, zinc iodide (10.38 g, 32.5 mmol),sodium cyanoborohydride (10.22 g, 162.7 mmol), and 1,2-dichloroethane(300 ml) was refluxed for 16 h. The reaction mixture was cooled to roomtemperature, filtered through Celite®, and then concentrated to dryness.Purification of the residue on a Florisil® column (hexane-acetone, 98:1)gave 3-(1-methylpyrrol-2-ylmethyl)nitrobenzene (3.55 g, 75%) as a solid.##STR44##

3-(1-Methylpyrrol-2-ylmethyl)nitrobenzene (2.0 g, 9.2 mmol) prepared asin Example 8, Step (b)!, 4-methylbenzoyl chloride (2.84 g, 18.4 mmol),and triethylamine (2.0 ml, 14.3 mmol) were dissolved in xylenes (80 ml)and the reaction mixture was refluxed for 36 h. Purification on aFlorisil column (hexane-ethyl acetate, 95:5) gave3-{5-(4-methyl-benzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}nitrobenzene (0.86g, 28%) as a solid. ##STR45##

A mixture of3-{5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl}-nitrobenzene (0.86g, 2.6 mmol) prepared as in Example 8, Step (c)!, nickel boride (1.0 g),10% HCl (13 ml), and methanol (35 ml) was heated at 65° C. for 40 min.The reaction mixture was cooled to room temperature, made basic withconcentrated ammonium hydroxide, and filtered through Celite®. Theproduct was extracted into ethyl acetate, and the organic extracts werewashed with water and brine, and dried over sodium sulfate. Evaporationof the organics gave3-{5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl}aniline (0.73 g,99%) as a solid.

Example 9 Synthesis of3,5-Difluoro-4-{5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl}aniline##STR46##

The ethyl ester of zomepirac (4.66 g, 15.2 mmol) and3,4,5-trifluorobenzonitrile (3.23 g, 20.6 mmol) were dissolved in DMF(75 ml) and NaH (60% in mineral oil, 1.28 g, 32.0 mmol) was added inportions under an argon atmosphere. The reaction mixture was heated at60° C. for 2.5 h, then cooled to room temperature and added slowly to amixture of ice/water (600 ml) containing 6N HCl (7.5 ml). The productwas filtered and dried under vacuum. Recrystallization from ethylacetate-hexane gave ethyl 2-5-(4-chlorobenzoyl)-1,4-dimethyl-pyrrol-2-yl!-2-(2,6-difluoro-4-cyanophenyl)acetate(5.67 g, 84% yield) as yellow crystals, mp 155-155.5° C. ##STR47##

To a slurry of ethyl 2-5-(4-chlorobenzoyl)-1,4-dimethylpyrrol-2-yl!-2-(2,6-difluoro-4-cyanophenyl)acetate(0.05 g, 0.11 mmol) prepared as described in Example 9, Step (a)! inmethoxyethanol (4 ml) was added an aqueous solution of lithium hydroxidemonohydrate (0.02 g in 0.5 ml H₂ O), and the reaction mixture was heatedat reflux under an argon atmosphere. After 24 hr, the reaction mixturewas cooled to room temperature and poured into a mixture of ice/water(40 ml) containing IN HCl (1 ml). The solid was filtered to give crude{4- 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!benzoic acid(0.037 g) as a tan solid. Flash chromatography on a silica gel column(0.5% acetic acid-30% acetone:hexane), followed by recrystallizationfrom methanol-acetone gave pure {4-5-(4-chloro-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!benzoic acid(0.032 g, 70.2% yield) as a white solid, mp 245-246.8° C. ##STR48##

Phosphoryl azide (1.0 ml, 4.61 mmol) was added to a mixture of (4-5-(4-chloro-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!benzoic acid(1.49 g, 3.69 mmol) prepared as described in Example 9, Step (b)!, andtriethylamine (0.77 ml, 5.54 mmol) in toluene at 0° C. under a nitrogenatmosphere. After stirring at room temperature for 10 min, the reactionmixture was heated to 100° C. over the course of 1 hr. After heating at100° C. for 1 h, the reaction mixture was cooled to room temperature andtrimethsilylethanol (1.06 ml, 7.38 mmol) was added. The reaction mixturewas reheated and maintained at 50° C. for 1 h under a nitrogenatmosphere, and then the solvent was removed by evaporation underreduced pressure. The resulting yellow oil was redissolved in THF (100ml) and tetrabutylammonium fluoride (10 ml, 1 M soln. in THF) was added.After heating the reaction mixture at reflux for 3 h the solvent wasremoved in vacuo, and the residue was partitioned between ethyl acetateand water. The organic extracts were washed with water, dried overmagnesium sulfate, and evaporated to give a yellow oil. Purification bychromatography on a silica gel column (25% ethyl acetate:hexane),followed by recrystallization from acetone-hexane gave3,5-difluoro-4-{5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl}aniline(0.64 g, 64.4% yield) as white crystals, mp 208.2-210° C.

Example 10 Synthesis of4-{5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl}phenol##STR49##

4-{5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl}aniline (1.36g, 4.0 mmol) prepared by the method described in Example 1, butsubstituting zomepirac methyl ester and 4-fluoronitrobenzene for ethyl5-benzoyl-1,4-dimethylpyrrole-2-acetate and 3,4-difluoro-nitrobenzenerespectively, in Step (b)!, was dissolved in acetic acid (20 ml), and asolution of 1N sulfuric acid in acetic acid (4.4 ml), followed byacetone (12.5 ml) was added. The reaction mixture was cooled to 6° C.and isoamyl nitrite (0.65 ml, 4.8 mmol) was added. After 1.5 h, themixture was poured into ether and stored at 2° C. for 6 h. The purpleprecipitate was filtered, washed with ether and then suspended inacetone (50 ml). After adding sulfuric acid (20 ml, 0.1N), the reactionmixture was stirred at 60° C. for 3 h and then diluted with ethylacetate and water. The organic layer was separated and washed withwater, and dried over sodium sulfate. The solvent was removed in vacuoto give a deep red residue (0.8 g). Purification by flash chromatography(hexane-ether, 6:4), followed by recrystallization from hexane-acetonegave 4-{5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl}phenol(213 mg, 16%) as a solid, mp 183.4-185.1° C.

Example 11 Synthesis of N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!pyridin-5-yl}acetamide. ##STR50##

A solution of N-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine(0.3 g, 0.88 mmol) prepared by the method described in Example 5, butsubstituting zomepirac methyl ester for tolmetin methyl ester in Step(a)! and acetic anhydride (0.375 ml, 3.96 mmol) in THF was stirred at 60° C. for 4 h. The solvents were removed under reduced pressure and theresidue was crystallized from hexane-chloroform to give N-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-acetamide(295 mg, 88%) as a solid, mp 194-195° C.

Example 12

Synthesis of N-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!pyridin-5-yl}formamide##STR51##

The mixed anhydride of formic and acetic acid was prepared by addingformic acid (1 ml, 98%) dropwise to acetic anhydride (2 ml) and heatingthe mixture at 55° C. for 2.5 h. This reagent (2.2 ml) was then added toa solution of N-{2-5-(4-chlorobenzoyl)-1,4-di-methyl-1H-pyrrol-2-yl-methyl!-pyridin-5-yl}amine(0.3 g, 0.88 mmol) in THF (7 ml), and the reaction mixture was heatedovernight at 60° C. The solvents were removed in vacuo and the residuewas crystallized from chloroform-hexane to give N-{2-5-(4-chloro-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}formamide(175 mg, 54%) as a solid, mp 166.6-167.7° C.

Example 13 Synthesis of 1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl)-3-(2-hydroxyethyl)urea ##STR52##

4-{5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl}aniline (0.33g, 0.98 mmol) and 1,1'-carbonyldiimidazole (0.4 g, 2.46 mmol) weredissolved in DMF, and the reaction mixture was stirred at roomtemperature for 1 h. Ethanolamine (0.3 ml, 4.91 mmol) was added andafter 1.5 h the mixture was diluted with water. The product wasextracted into ethyl acetate, and the organic layer was dried over MgSO₄and then concentrated under vacuum. Purification by flash chromatography(ethyl acetate), followed by recrystallization from hexane-chloroformgave 1-{4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-(2-hydroxyethyl)urea(239 mg, 57%) as a solid, mp 209.6-210.2° C.

Example 14 Synthesis of 1-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!pyridin-5-yl}-3,3-dimethylurea##STR53##

{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amineprepared by the method described in Example 5, but substituting themethyl ester of zomepirac for the methyl ester of tolmetin in Step (a)!(0.45 g, 1.32 mmol) and dimethylcarbamoyl chloride (0.13 ml, 1.46 mmol)were dissolved in pyridine (6.6 ml), and the mixture was stirred at roomtemperature for 96 h. The solvents were removed in vacuo and the residuewas crystallized from chloroform-hexane mixture to give 1-(2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3,3-dimethylurea(0.31 g, 57%) as a solid, mp 227.2-230.0° C.

Example 15 Synthesis of 1-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!pyridin-5-yl)-3-methylurea##STR54##

{2-{5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine(0.3 g, 0.88 mmol) was dissolved in THF (4 ml), and the solution wascooled to 0° C. Methyl isocyanate (0.062 ml, 1.06 mmol) was added andthe reaction mixture was stirred overnight at ambient temperature.Additional methyl isocyanate (0.062 ml) was added and the mixture wasstirred for an additional 24 h. The reaction mixture was concentratedunder vacuum and the residue was crystallized from hexane-chloroform togive 1-{2-5-(4-chlorobenzoyl)-1,4-di-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methylurea(240 mg, 69%), mp 234.0-235.5° C.

Example 16 Synthesis of 1-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!pyridin-5-yl}-3-methyl-2-thiourea##STR55##

N-{2-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine(0.3 g, 0.88 mmol) and methylisothiocyanate (0.3 ml, 4.4 mmol) weredissolved in THF and the reaction mixture was stirred at 60° C.overnight. The mixture was diluted with ethyl acetate and washed with 1NHCl 10% sodium bicarbonate, water, and brine. The solvents were removedin vacuo and the crude product was purified by flash chromatography(ethyl acetate-methanol, 97:3) to give 1-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-3-methyl-2-thiourea(265 mg, 73%) as a solid, mp 135° C.

Example 17 Synthesis of N-{3-Fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}methanesulfonamide##STR56##

3-Fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline (1.0 g,3.1 mmol) prepared as described in Example 1! was dissolved in pyridine(10 ml) and the solution was cooled to -5° C. Methanesulfonyl chloride(0.39 g, 3.4 mmol) was added and after 1 h the reaction mixture waspoured into 1 M HCl/ice/water and extracted with ethyl acetate. Theorganic layer was washed with water, dried over sodium sulfate andconcentrated to dryness. The residue was crystallized from methylenechloride-methanol to give N-(3-fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide(775 mg, 62%) as a solid, mp 165-167° C.

Proceeding as described in Example 17, but substituting 3-Cyano-4-5-(4-chloro-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline preparedby the method described in Example 4, but substituting the sodium saltof zomepirac for the sodium salt of tolmetin in Step (a) and3-cyano-4-chloronitrobenzene for 3,4-dichloronitrobenzene in Step (b)!,for 3-fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline gaveN-{3-cyano-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide.

Proceeding as described in Example 17, but substituting {2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine,prepared by the method described in Example 5, but substituting thezomepirac methyl ester for the tolmetin methyl ester in Step (a)!, for3-fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline gaveN-{2-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}methane-sulfonamide.

Proceeding as described in Example 17, but substituting {2-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amine,prepared by the method described in Example 5!, for 3-Fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline gave N-{2-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.

Proceeding as described in Example 17, but substituting 3-fluoro-4-5-(2-methoxy-benzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline prepared bythe method described in Example 1, but substituting 2-methoxybenzoylchloride and methyl 1-methylpyrrole-2-acetate for benzoyl chloride andethyl 1,4-dimethylpyrrole-2-acetate, respectively in Step (a)! for3-fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-yl-methyl!aniline gaveN-{3-fluoro-4-5-(2-methoxybenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}-methanesulfonamide.

Proceeding as described in Example 17, but substituting {3-chloro-2-5-(4-methoxy-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amineprepared by the method described in Example 4, but substituting methyl5-(4-methoxybenzoyl)-1,4-dimethylpyrrole-2-acetate for the sodium saltof tolmetin in step (a) and 2,3-dichloro-4-nitropyridine for3,4-dichloronitrobenzene in Step (b)!, for 3-fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline gave N-{3-chloro-2-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!pyridin-5-yl}methanesulfonamide.

Proceeding as described in Example 17, but substituting {2-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amineprepared by the method described in Example 5, but substituting themethyl ester of tolmetin for methyl5-(4-methylbenzoyl)-1-methylpyrrole-2-acetate in Step (b)!, for3-fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline gaveN-{2-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-pyridin-5-yl}methanesulfonamide.

Example 18 Synthesis of N-{3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}-2-(hydroxy)ethanesulfonamide.##STR57##

3-Fluoro-4- 5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!aniline (0.75 g,2.43 mmol) prepared as described in Example 1, but substituting ethyl1,4-dimethylpyrrole-2-acetate with methyl 1-methylpyrrole-2-acetate inStep (a)!, and pyridine (0.39 ml, 4.88 mmol) were dissolved in methylenechloride (8 ml). 2-Acetoxyethanesulfonyl chloride (681 mg, 3.65 mmol)was added to the solution and after 15 min, the reaction mixture waspartitioned between ethyl acetate and water. The organic layer wasseparated, washed with brine, dried over sodium sulfate and concentratedto dryness. Purification of the residue by flash chromatography(hexane-ethyl acetate, 3:2) gave N-{3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!-phenyl}-2-(acetoxy)ethanesulfonamide,(643 mg, 58%) as a solid. ##STR58##

N-{3-Fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(acetoxy)-ethanesulfonamide(0.415 g, 0.905 mmol) prepared as in Example 18, Step (a)! was dissolvedin methanol (5 ml) and a 2.0 M solution of ammonia in methanol (4.53 ml,9.05 mmol) was added. The mixture was stirred for 60 h, after which itwas concentrated to dryness. Purification of the residue by flashchromatography gave N-{3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide(282 mg, 75%) as a solid.

Proceeding as described in Example 18, but substituting 3-fluoro-4-5-(2,4-di-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline preparedby the method described in Example 6!, for 3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!aniline gave N-{3-fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.

Proceeding as described in Example 18, but substituting 3-fluoro-4-5-(4-methyl-benzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline prepared bythe method described in Example 1, but substituting the methyl ester oftolmetin for ethyl 5-benzoyl-1,4di-methylpyrrole-2-acetate in step (b)!,for 3-fluoro-4- 5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!aniline gaveN-{3-fluoro-4-5-(4-nethylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

Proceeding as described in Example 18, but substituting 3-fluoro-4-5-(4-methoxy-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline preparedby the method described in Example 1, but substituting 4-methoxybenzoylchloride for benzoyl chloride in step (a)!, for 3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!aniline gave N-{3-fluoro-4-5-(4-methoxybenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)-ethanesulfonamide.

Example 19 Synthesis of N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}ethenesulfonamide##STR59##

4- 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline (1.1 g,3.25 mmol) was dissolved in pyridine (16.5 ml) and2-chloroethanesulfonyl chloride (1.02 ml, 9.74 mmol) was added to thesolution. The mixture was stirred for 1.5 h and then concentrated todryness. The residue was filtered through a pad of silica gel (ethylacetate) to give N-{4-5-(4-chloro-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}ethenesulfonamide,(1.29 g, 93%) as a solid.

Example 20 Synthesis of N-{4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl)-2-(dimethylamino)ethanesulfonamidehydrochloride ##STR60##

N-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-ethenesulfonamide(250 mg, 0.583 mmol) prepared as in Example 19!, was dissolved in DMF(1.1 ml). Triethylamine (0.11 ml, 0.8 mmol), followed by dimethylaminehydrochloride (36 mg, 0.69 mmol), was added and the reaction mixture wasstirred for 1 h. A second batch of trimethylamine and dimethyaminehydrochloride was added and the stirring was continued overnight. Thereaction mixture was partitioned between ethyl acetate and water, andthe organic layer was separated and dried over sodium sulfate. Thesolvent was removed in vacuo and the crude product was then dissolved inethyl acetate, after which ethanolic HCl was added to give N-{4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(dimethyl-amino)ethanesulfonamide(257 mg, 86%) as the hydrochloride salt

Example 21 Synthesis of N-{4-5-(4-aminobenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}methanesulfonamide##STR61##

Methyl 1-methylpyrrole-2-acetate (5.32 g, 34.73 mmol) and4-fluoro-nitrobenzene (4.9 g, 34.73 mmol) were dissolved in dry DMF (100ml), and the solution was cooled to 0° C. under nitrogen. Sodium hydridepowder (1.75 g, 72.93 mmol) was added in portions. After 30 min thereaction mixture was quenched with 1 M HCl and the product was extractedinto ether. The organic extracts were washed with water and brine, anddried over magnesium sulfate. The solvent was removed in vacuo to givemethyl-2-(1-methylpyrrol-2-yl)-2-(4-nitrophenyl)acetate (9.20 g, 97%) asa red oil. ##STR62##

Methyl 2-(1-methylpyrrol-2-yl)-2-(4-nitrophenyl)acetate (9.2 g, 33.54mmol) prepared as in Example 21, Step (a)!, was dissolved in methanol(100 ml) and an aqueous solution of lithium hydroxide (3.52 g in 50 mlof water) was added. After 1.5 h the reaction mixture was concentratedto dryness in vacuo and the resulting residue was dissolved in water(100 ml). The solution was acidified to pH 1 with 6 M HCl and thenextracted with ethyl acetate. The organic extracts were washed withwater, and brine, and dried over magnesium sulfate. The solvent wasremoved in vacuo and the residue was purified by flash chromatography(hexane-ethyl acetate, 9:1) to give4-(1-methylpyrrol-2-ylmethyl)nitrobenzene (4.8 g, 66%) as a yellow oil.##STR63##

4-(1-Methylpyrrol-2-ylmethyl)nitrobenzene (500 mg, 2.31 mmol) preparedas described in Example 21, Step (b)!, was dissolved in ethyl acetateand subjected to hydrogenation over 5% Pd/C (50 mg) at ambienttemperature and atmospheric pressure. After 3 h the mixture was filteredand the filtrate was concentrated to give4-(1-methylpyrrol-2-yl-methyl)aniline (430 mg, 100%) as a yellow oil.##STR64##

A mixture of 4-(1-methylpyrrol-2-ylmethyl)aniline (3.21 g, 17.23 mmol)prepared as in Example 21, Step (c)!, and triethylamine (8.4 ml, 60.27mmol) was cooled to 0° C. under nitrogen. Methanesulfonyl chloride (4.2ml, 54.26 mmol) was added and after for 1.5 h the reaction mixture wasdiluted with methylene chloride. The organic layer was separated andwashed with 1 M aqueous sodium bisulfate, and brine and then dried overmagnesium sulfate. Evaporation gaveN-{4-(1-methylpyrrol-2-ylmethyl)phenyl}bismethanesulfonamide (6.63 g) asan orange foam which was used in step (e) without further purification.##STR65##

N,N-dimethyl-4-nitrobenzamide (0.65 mg, 3.36 mmol) and phosphorusoxychloride were stirred together until the mixture became homogeneous.A solution ofN-{4-(1-methylpyrrol-2-ylmethyl)-phenyl}-bis-methanesulfonamide (1.15 g)prepared as described in Example 21, Step (d)!, in dry dichloroethane(15 ml) was added and the stirring was continued overnight. Sodiumbicarbonate (17 ml, 10% solution in water) was added and after 1.5 h thereaction mixture was cooled to room temperature, and diluted withmethylene chloride. The organic layer was separated and washed withwater and brine, and dried over magnesium sulfate. The solvent wasremoved in vacuo and the residue was purified by flash chromatography(hexane-ethyl acetate, 3:2) to give N-{4-5-(4-nitro-benzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-phenyl}bismethanesulfonamide(0.35 g, 25%) as an oil. ##STR66##

4-{5-(4-Nitrobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}bismethanesulfonamide(0.35 g, 0.712 mmol) prepared as in Example 21, Step (e)!, was dissolvedin dioxane (4 ml) and an aqueous solution of lithium hydroxide (60 mg,1.42 mmol in 1 ml of water) was added. After stirring for 60 h themixture was partitioned between ethyl acetate and a 1 M sodium bisulfatesolution. The organic layer was separated, washed with brine, and driedover sodium sulfate. Concentration gave N-{4-5-(4-nitrobenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}methanesulfonamide(294 mg) as a dark yellow oil which was used in the next step withoutfurther purification. ##STR67##

N-{4- 5-(4-Nitrobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide(294 mg) prepared as in Example 21, Step (f)!, and an aqueous solutionof ammonium chloride (0.3 g/2.5 ml water) were dissolved in ethanol (5ml). Iron powder (0.2 g) was added and the reaction mixture was heatedat reflux for 20 min. The mixture was filtered and the filter cake waswashed with methylene chloride. The filtrate was diluted with ethylacetate, washed with water, and brine, and dried over sodium sulfate.The solvent was removed in vacuo and the residue was purified by flashchromatography (hexane-ethyl acetate, 3:2). Recrystallization of theproduct from hexane-ethyl acetate gave N-{4-5-(4-aminobenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methanesulfonamide(175 mg, 64%) as a yellow powder.

Example 22 Synthesis of 1-{3-fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}-3,3-dimethylsulfamide##STR68##

3-Fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline (1.0 g,3.1 mmol) prepared by the method described in Example 1!, andN,N-dimethylsulfamoyl chloride (894 mg, 6.2 mmol) were dissolved inpyridine (10 ml) and stirred at 50° C. for 12 h. The reaction mixturewas poured into 1 M HCl/ice/water and extracted with ethyl acetate. Theorganic layer was separated, washed with water, dried over sodiumsulfate and concentrated to dryness. The residue was triturated withmethanol, filtered and then purified by preparatory thin layerchromatography TLC (hexane-ethyl acetate, 3:2). Crystallization from achloroform-hexane mixture gave 1-{3-fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}-3,3-dimethylsulfamide(343 mg, 26%), mp 182-182° C.

Proceeding as described in Example 22, but substituting 4-5-(4-chlorobenzoyl)-1,4-di-methyl-1H-pyrrol-2-ylmethyl!aniline preparedby the method described in Example 1, but substituting methyl ester ofzomepirac and 4-fluoronitrobenzene for ethyl5-benzoyl-1,4di-methylpyrrole-2-acetate and 3,4-difluoronitrobenzenerespectively in Step (b)!, for

3-fluoro-4- 5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline gave1-{4-5-(4-chloro-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-dimethylsulfamide.

Example 23 Synthesis of 1-(3-Fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}sulfamide##STR69##

A 1 M solution of aminosulfamoyl chloride was prepared by addition of asolution of water (1.44 g, 80.0 mmol) in ethylene glycol dimethyl ether(20 ml) to a solution of chlorosulfonyl isocyanate (7.0 ml, 80.0 mmol)in ethylene glycol dimethyl ether (60 ml) under nitrogen at -45° C. Thereaction mixture was allowed to warm to room temperature slowly. Thisreagent solution (1.0 ml, 1.0 mmol) was added to a solution of3-fluoro-4- 5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline(322 mg, 1.0 mmol) and triethylamine (0.14 ml, 1.2 mmol) in drymethylene chloride at 5 ° C. under nitrogen. After 35 min, additionalamounts of triethylamine (0.7 ml, 0.6 mmol) and aminosulfamoyl chloridesolution (0.5 ml, 0.5 mmol) were added, and the reaction mixture wasstirred for an additional 15 min. The reaction mixture was diluted withethyl acetate and water, and the organic layer was separated, washedwith 1 M sodium bisulfate and brine, and dried over magnesium sulfate.The solvent was removed in vacuo and the solid residue was trituratedwith ether to give 1-{3-fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-phenyl}sulfamide (303mg, 75%) as a tan powder.

Proceeding as described in Example 23, but substituting 3-fluoro-4-5-(2,4-dimethyl-benzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline preparedby the method described in Example 6!, for 3-fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!aniline gave1-{3-fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}-sulfamide.

Proceeding as described in Example 23, but substituting 3-fluoro-4-5-(4-chloro-benzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline preparedby the method described in Example 1, but substituting the methyl esterof zomepirac for ethyl 5-benzoyl-1,4-dimethyl-pyrrole-2-acetate in Step(b)!, for 3-fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!aniline gave1-{3-fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!-phenyl}sulfamide.

Proceeding as described in Example 23, but substituting 3-cyano-4-5-(4-methoxy-benzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline prepared bythe method described in Example 6, but substituting 4-methoxybenzoylchloride for 2,4-dimethy-lbenzyol chloride in Step (b) and3-cyano-4-chloronitrobenzene for 3,4-difluoro-nitrobenzene in Step (c)!,for 3-fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!aniline gave1-{3-cyano-4-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}sulfamide.

Proceeding as described in Example 23, but substituting {2-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}amineprepared by the method described in Example 5, but substituting themethyl ester of tolmetin for methyl5-(4-methylbenzoyl)-1-methylpyrrole-2-acetate in Step (b)!, for3-fluoro-4- 5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!anilinegave 1-{2-5-(4-nethoxybenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!pyridin-5-yl}sulfamide.

Example 24 Synthesis of 1-{4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}-3-sulfamorpholide##STR70##

1-{4-5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3,3-di-methylsulfamide(75 mg, 0.188 mmol) and triethylamine (0.047 ml, 0.376 mmol) weredissolved in benzene (0.4 ml). The reaction mixture was stirred for 15min and then concentrated in vacuo. The yellow solid residue wasredissolved in 1.0 ml of morpholine and heated at 65° C. for 24 h. Thereaction mixture was partitioned between ethyl acetate and 5% aqueousHCl. The organic layer was separated, washed with water, and brine, anddried over sodium sulfate. Crystallization of the crude product fromhexane-ethyl acetate gave 1-{4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-3-sulfa-morpholide(49 mg, 53%) as a solid, mp 126-127° C.

Example 25 Synthesis of N-{2-hydroxy-4-5-(4-chlorobenzoyl-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}methanesulfonamide.##STR71##

N-{2-Benzyloxy-4-5-(4-chlorobenzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide(0.31 g, 0.59 mmol) was dissolved in ethyl acetate (50 ml). 10% Pd/C (93mg) was added and the mixture was stirred under H₂ atmosphere for 2h.The mixture was filtered through Celite® and the filtrate was evaporatedto give a solid. Crystallization from hexane-acetone gaveN-{2-hydroxy-4-5-(4-chlorobenzoyl-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}-methanesulfonamide(200 mg, 78%) as a solid, mp 205° C. (dec.)

Example 26

Synthesis of N-{3-carboxy-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}methanesulfonamide##STR72##

N-{3-Methoxycarbonyl-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl-methyl!phenyl}methanesulfonamide(735 mg, 1.54 mmol) and 2.5N sodium hydroxide

(2.5 ml) were dissolved in a 1:1 mixture of methanol-THF (40 ml) andstirred at room temperature for 64 h. The mixture was diluted withwater, acidified to pH 2 with 2.0N HCl, and extracted with ethylacetate. The organic extracts were washed with brine, dried over sodiumsulfate and concentrated to dryness. Crystallization from methylenechloride-methanol gave N-{3-carboxy-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!phenyl}-methanesulfonamide(500 mg, 70%) as a solid, mp 248-250° C. (dec.).

Example 27 Synthesis of N-{3-cyano-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!-phenyl}methanesulfonamide##STR73##

N-{3-Bromo-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}methane-sulfonamide(320 mg, 0.69 mmol) was dissolved in DMF. CuCN (120 mg, 1.38 mmol) wasadded and the suspension was refluxed for 4 h. The mixture was cooled toroom temperature, and NaCN (2.0 g in 10 ml of water) was added. After0.5 h the mixture was extracted with ethyl acetate and the extracts werewashed with water, and brine, and dried over sodium sulfate. The solventwas removed in vacuo and the residue was purified by preparatory TLC(hexane-ethyl acetate) to give N-{3-cyano-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-yl-methyl!phenyl}methanesulfonamide(190 mg, 67%) as a solid, mp 171-172° C.

Example 28 Synthesis of 3-fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline ##STR74##

3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline (5.0 g,14.0 mmol), sodium acetate (1.15 g, 14 mmol) and 10% Pd/C (475 mg) weresuspended in ethanol (230 ml). The reaction mixture was shaken in a Parrapparatus under hydrogen atmosphere at 30 psi overnight. The mixture wasfiltered through Celite® and the filtrate was evaporated to dryness. Thecrude product was purified on a silica gel column (methylenechloride-methanol, 99:1) and then crystallized from ethylacetate/hexane/cyclohexane to give 3-fluoro-4-5-benzoyl-1,4-dimethyl-1H-pyrrol-2-yl-methyl!aniline (2.49 g, 55%) as asolid.

Example 29 Synthesis of 3-fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline##STR75##

3-Fluoro-4-5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline (2.0 g,5.6 mmol) was dissolved in degassed DMF. Sodium thiomethoxide (1.5 g,22.4 mmol) was added and the mixture stirred at room temperature underargon for 24 h. The reaction was poured into ice-water, acidified withacetic acid to pH 3 and extracted with ethyl acetate. The organicextracts were washed with water, and brine, and dried over magnesiumsulfate. The solvent was removed in vacuo and the crude product waspurified on a silica gel column (methylene chloride-methanol-acetone,96:2:2) to give 3-fluoro-4-5-(4-methylthiobenzoyl)-1,4-dimethyl-1H-pyrrol-2-ylmethyl!aniline (1.13g, 55%) as a solid, mp 199.1-199.7° C.

Example 30 The following are representative pharmaceutical formulationscontaining a compound of formula I. Tablet Formulation

The following ingredients are mixed intimately and pressed into singlescored tablets.

    ______________________________________                      Quantity per    Ingredient        tablet, mg    ______________________________________    compound of this invention                      400    cornstarch        50    croscarmellose sodium                      25    lactose           120    magnesium stearate                      5    ______________________________________

Capsule Formulation

The following ingredients are mixed intimately and loaded into ahard-shell gelatin capsule.

    ______________________________________                      Quantity per    Ingredient        capsule, mg    ______________________________________    compound of this invention                      200    lactose, spray-dried                      148    magnesium stearate                      2    ______________________________________

Suspension Formulation

The following ingredients are mixed to form a suspension for oraladministration.

    ______________________________________    Ingredient            Amount    ______________________________________    compound of this invention                          1.0 g    fumaric acid          0.5 g    sodium chloride       2.0 g    methyl paraben        0.15 g    propyl paraben        0.05 g    granulated sugar      25.5 g    sorbitol (70% solution)                          12.85 g    Veegum K (Vanderbilt Co.)                          1.0 g    flavoring             0.035 ml    colorings             0.5 mg    distilled water       q.s. to 100 ml    ______________________________________

Injectable Formulation

The following ingredients are mixed to form an injectable formulation.

    ______________________________________    Ingredient             Amount    ______________________________________    compound of this invention                           0.2 g    sodium acetate buffer Solution, 0.4 M                           2.0 ml    HCl (1N) or NaOH (1N)  q.s. to suitable pH    water (distilled, sterile)                           q.s. to 20 ml    ______________________________________

Topical Formulation

A topical formulation is prepared with the following ingredients.

    ______________________________________    Ingredient              Amount, g    ______________________________________    compound of this invention                            10    Span 60                 2    TWEEN ®60           2    mineral oil             5    petrolatum              10    methyl paraben          0.15    propyl paraben          0.05    BHA (butylated hydroxy aniole)                            0.01    water                   q.s. to 100    ______________________________________

All of the above ingredients, except water, are combined and heated to60-70° C. with stirring. A sufficient quantity of water at 60° C. isthen added with vigorous stirring to emulsify the ingredients, and waterthen added q.s. to 100 g.

Suppository Formulation

A suppository of total weight 2.5 g is prepared by mixing the compoundof the invention with Witepsol® H-15 (triglycerides of saturatedvegetable fatty acid; Riches-Nelson, Inc., New York), and has thefollowing composition:

    ______________________________________    compound of the invention                       500 mg    Witepsol ® H-15                       balance    ______________________________________

Example 31 Inhibition of COX I and COX II in vitro

The COX I and COX II inhibitory activity of compounds of this inventionin vitro was determined using partially purified COX I and COX IIenzymes, prepared as described in J. Barnett et al., Biochim. Biophys.Acta, 1209:130--139 (1994).

COX I and COX II samples were diluted with Tris-HCl buffer (50 mMTris-HCl pH 7.9) containing 2 mM EDTA and 10% glycerol and reconstitutedby incubating first with 2 mM phenol for 5 minutes and then with 1micromolar hematin for an additional 5 minutes. 125 μl of thereconstituted COX I or COX II enzyme were preincubated for 10 minutes atroom temperature in a shaking water bath with the compounds of theinvention dissolved in 2-15 μl of DMSO or the carrier vehicles (controlsamples). The enzyme reaction was initiated by adding 25 μl of 1- 14C!arachidonic acid (80,000-100,000 cpm/tube; 20 micromolar finalconcentration) and the reaction was allowed to continue for anadditional 45 seconds. The reaction was terminated by adding 100 μl of2N HCl and 750 μl water. An aliquot (950 μl) of the reaction mixture wasloaded onto a 1 ml C₁₈ Sep-Pak column (J. T. Baker, Phillipsburg, N.J.)which had been previously washed with 2-3 ml methanol and equilibratedwith 5-6 ml distilled water. Oxygenated products were quantitativelyeluted with 3 ml of acetonitrile/water/acetic acid (50:50:0.1, v/v) andthe radioactivity in the eluate determined in a scintillation counter.

Compounds of this invention were active in this assay.

The COX inhibitory activities (expressed as IC₅₀, the concentrationcausing 50% inhibition of the COX enzyme being assayed) of somecompounds of the invention and indomethacin as a comparator, were:

    ______________________________________           COX I    COX II          COX I   COX II    CPD#   IC.sub.50, μM                    IC.sub.50, μM                             CPD#   IC.sub.50, μM                                            IC.sub.50, μM    ______________________________________    1      11       0.15     206    0.46    0.24    11     7.5      0.51     222    0.46    0.074    19     0.76     0.08     223    0.064   0.029    27     415      0.063    226    100     2.1    28     33       0.19     227    2.5     0.1    31     3.9      0.045    228    8.5     0.1    36     10       0.05     235    8.2     0.17    38     0.27     0.065    236    15      0.51    48     61       0.08     243    100     8.9    60     0.16     0.028    250    34      27.4    63     0.035    0.33     251    310     0.64    66     6.9      0.12     263    49      0.45    68     0.86     0.073    267    210     0.7    71     38       0.16     271    89      0.43    72     265      0.7      272    >1000   2.1    88     <0.1     0.06     276    60      0.5    95     0.09     0.06     284    22      0.50    97     <0.1     0.038    288    235     0.55    98     <0.1     0.23     289    10.2    1.5    104    0.75     0.24     294    9.1     2.6    106    0.95     0.07     295    0.60    0.10    131    0.20     0.077    296    0.21    0.40    133    0.045    0.058    306    113     0.64    140    5.4      0.12     308    650     8.75    141    3.9      0.03     310    142     9.2    146    2.9      0.06     314    65      0.56    147    0.6      0.1      316    360     0.20    154    34       0.054    329    256     43.7    165    16.8     0.095    330    61.1    30    172    43       0.09     333    NA      78.4    177    0.79     0.30     334    18.3    0.64    196    5.0      0.04     340    0.02    0.06    197    <0.1     0.07     343    6.6     0.54    202    3.2      0.05     Indo-  0.4     14                             methacin    ______________________________________

Example 32 Anti-inflammatory Activity

The anti-inflammatory activity of compounds of this invention wasdetermined by measuring the inhibition of carrageenan-induced paw edemain the rat, using a modification of the method described in Winter C. A.et al. (1962) "Carrageenan-Induced Edema in Hind Paw of the Rat as anAssay for Anti-inflammatory Drugs". Proc. Soc. Exp. Biol. Med. 111:544-547. This assay has been used as a primary in vivo screen foranti-inflammatory activity of most NSAIDs, and is considered predictiveof human efficacy. Briefly, test materials were administered orally tofemale rats in a volume of 1 ml prepared as solutions or suspensions inan aqueous vehicle containing 0.9% NaCl, 0.5% sodiumcarboxymethyl-cellulose, 0.4% polysorbate 80, 0.9% benzyl alcohol and97.3% distilled water. Control rats received vehicle alone. After 1 h0.05 ml of a 0.5% solution of Carrageenan (Type IV Lambda, SigmaChemical Co.) in 0.9% saline was injected into the subplantar region ofthe right hind paw. Three hours later the rats were euthanized in acarbon dioxide atmosphere; hind paws were removed by severing at thetatso-crural joint; and the left and right paws were weighed. Theincrease in weight of the right paw over the left paw was obtained foreach animal and the mean increases were calculated for each group. Theanti-inflammatory activity of the test materials is expressed as thepercent inhibition of the increase in hind paw weight of the test grouprelative to the vehicle-dosed control group.

Compounds of this invention were active in this assay.

The anti-inflammatory activities (expressed as % inhibition) of some ofthe compounds of the invention at 10 mg/Kg were:

    ______________________________________    CPD#    % Inhibition   CPD#    % Inhibition    ______________________________________    19      36             146     40    36      31             165     17    48      35             263     40    98      42             288     20    140     27             343     35    ______________________________________

Example 33 Inhibition of Eicosanoid Synthesis in vivo

The activity of compounds of this invention in inhibiting in vivoeicosanoid (prostaglandin E₂) synthesis in inflamed tissues wasdetermined by the carrageenan-induced inflammation (air-pouch model) inrats, using a modification of the method described in Futaki, M., etal.; (1993) "Selective Inhibition of NS-398 on prostanoid production ininflamed tissue in rat Carrageenan Air-pouch Inflammation" J. Pharm.Pharmacol. 45:753-755, and Masferrer, J. L., et al.; (1994) "SelectiveInhibition of inducible cyclooxygenase 2 in vivo is Antiflammatory andNonulcerogenic" Proc. Natl. Acad. Sci. USA. 91: 3228-3232. In thisassay, an air-pouch is created in the rat and the PGE₂ levels in theair-pouch exudate are measured by enzyme immunoassay. Briefly, male ratswere anesthetized using a 60:40 CO₂ :O₂ mixture and subsequentlyinjected subcutaneously with 20 ml of sterilized air, under asepticconditions, in the proximal area of the dorsum. This injection ofsterile air causes the creation of a subcutaneous "air pouch". The nextday, a further 10 ml of sterile air was injected into the previouslyformed pouch using the same technique. The test materials wereadministered orally in a volume of 1 ml/100 g body weight as solutionsor suspensions in an aqueous vehicle containing 0.9% NaCl, 0.5% sodiumcarboxymethyl-cellulose, 0.4% polysorbate 80, 0.9% benzyl alcohol and97.3% water. Control rats received vehicle alone. After 30 minutes, 5 mlof a 0.5% solution of carrageenan (Sigma, Lambda Type IV) was injectedinto the air pouch. The rats were euthanized 3 or 6 h after the compoundadministration. 10 ml of a solution containing 10 μg/l of indomethacinand 5.4 mM EDTA in 0.9% sterile saline was injected into the air pouch;the air pouch was cut open; and the exudate was harvested. The totalexudate volume was recorded, and the samples were analyzed for PGE₂ and6-keto PGF₁ by ELISA (Titerzyme®, PerSeptive Diagnostics) and TxB₂ byradioimmuno assay (New England Nuclear Research, Catalog No. NEK-037),according to the manufacturer's directions.

The mean concentrations of PGE₂ were calculated for each group. Theanti-inflammatory activity of test materials is expressed as the percentinhibition of PGE₂ formation in the test group relative to the controlgroup.

Compounds of this invention were active in this assay.

The anti-inflammatory activities (expressed as % inhibition of air pouchPGE₂ formation) of some of the compounds of this invention andindomethacin as a comparator were:

    ______________________________________    CPD#       Dose mg/Kg   % Inhibition                                      Time    ______________________________________    19         10           74%       3 hr     36        10           96%       3 hr     48        30           64%       3 hr     98        10           98%       3 hr    140        30           83%       6 hr    146        10           93%       3 hr    165        10           52%       3 hr    236        30           71%       6 hr    263        30           80%       6 hr    271        10           56%       3 hr    284        10           65%       3 hr    288        10           53%       3 hr    334        10           44%       3 hr    Indomethacin               2-5          >70%    ______________________________________

Example 34 Analgesic Activity

The analgesic activity of compounds of this invention may be determinedby the Acetic Acid-induced Rat Writhing Assay, using a modification ofthe method described in Berkenkopf, J. W. and Weichman, B. M."Production of Prostacyclin in Mice following Intraperitoneal Injectionof Acetic Acid, Phenylbenzoquinone and Zymosan: Its Role in the WrithingResponse" Prostaglandins: 36: 693-70 (1988). This assay is one ofseveral acute assays which have been used to assess the analgesicactivity of NSAIDs, and is considered predictive of human efficacy. Thetest materials were administered orally to male Sprague Dawley rats in avolume of 1 ml/100 g body weight as solutions or suspensions in anaqueous vehicle containing 0.9% NaCl 0.5% sodiumcarboxymethyl-cellulose, 0.4% polysorbate 80, 0.9% benzyl alcohol and97.3% water. Control rats received vehicle alone. One hour aftercompound administration, 0.3 ml/100 g body weight of 0.75% solution ofacetic acid was injected intraperitoneally. The acetic acid injectioninduces a series of characteristic writhing responses, which werecounted over the period between 15 and 30 minutes after the injection.The analgesic activity of test materials is expressed as the percentageinhibition of writhing in the test group relative to the control group.

Compounds of this invention were active in this assay. The analgesicactivities (expressed as % inhibition of writhing responses) of some ofthe compounds of this invention at 10 mg/Kg were:

    ______________________________________    CPD#    % Inhibition   CPD#    % Inhibition    ______________________________________    36      16             140      4    98      71             263     31    ______________________________________

The analgesic activity of compounds of this invention may also bedetermined using an adjuvant-induced arthritis pain model in the rat,where pain is assessed by the animal's vocal response to the squeezingor flexing of an inflamed ankle joint, as described in Winter C. A. andNuss, G. W. (1966) "Treatment of Adjuvant Arthritis in rats withAntiinflammatory Drugs" Arthritis Rheum. 9: 394-403 and Winter, C. A.,Kling P. J., Tocco, D. J., and Tanabe, K. (1979). "Analgesic activity ofDiflunisal MK-647; 5-(2,4-Difluorophenyl)salicylic acid! in Rats withHyperalgesia Induced by Freund's Adjuvant" J. Pharmacol. Exp. Ther. 211:678-685.

What is claimed is:
 1. A compound selected from the group of compoundsrepresented by formula I: ##STR76## where: R₁ and R₅ are independently Hor alkyl;R₃ and R₄ are independently H, halo, alkyl, alkyloxy, oralkylthio; R₁₀ is a group represented by formula (A), (B) or (C):##STR77## where: R₁₂ and R₁₆ are independently H, halo, alkyl, alkyloxy,alkylthio, cyano, or hydroxy; R₁₃ and R₁₅ are independently H, halo,alkyl, alkyloxy, or alkylthio; and R₁₄ is H, halo, alkyl, haloalkyl,amino, alkylamino, dialkylamino, alkyloxy, hydroxy, alkylthio,alkenyl,alkynyl, cyano, --SO₂ R₁₇ where R₁₇ is alkyl, or --SO₂ NR₁₈ R₁₉ whereR₁₈ and R₁₉ are independently H or alkyl;provided that at least two ofR₁₂, R₁₃, R₁₄, R₁₅ and R₁₆ are H, and that if only two of R₁₂, R₁₃, R₁₄,R₁₅, and R₁₆ are H, the non-hydrogen substituents are not all adjacent;or R₁₂, R₁₅, and R₁₆ are H and R₁₃ and R₁₄ together are --OCH₂ O--; R₂₀is a group represented by formula (U), (V) or (W): ##STR78## where: R₂₂is H, halo, alkyl, cyano, trifluoromethyl, hydroxy, alkyloxy, or --CO₂R₂₇ where R₂₇ is H or alkyl; one of R₂₃, R₂₄, and R₂₅ is R₃₀ ; andeither all the remaining R₂₃, R₂₄, R₂₅, and R₂₆ are H; or one of theremaining R₂₃, R₂₄, R₂₅, and R₂₆ is halo, alkyl, cyano, trifluoromethyl,hydroxy, or alkyloxy; and R₃₀ is --OH*, --NHH*, --NH*CHO, --NH*C(X)R₃₁,--NH*SO₂ R₃₁, --NH*C(X)NR₃₂ R₃₃, or --NH*SO₂ NR₃₂ R₃₄,where: H* ishydrogen, optionally replaced by an in vivo hydrolyzable protectinggroup; R₃₁ is alkyl, haloalkyl, hydroxyalkyl, alkenyl, benzyl, aryl,cycloamino, --CH₂ SO₂ Me, or --(CH₂)_(n) R₃₅, where n is an integer from2 to 5 and R₃₅ is alkylamino, dialkylamino, cycloamino, alkyloxy,acyloxy, or --CO₂ R₂₇ ; R₃₂ is H, alkyl, or --(CH₂)_(n) OR₂₇ ; R₃₃ is H,alkyl, haloalkyl, aryl, hydroxyalkyl, tetrahydrofuran-2-ylmethyl, --CH₂CO₂ R₂₇, or --(CH₂)_(n) R₃₅ ; and R₃₄ is H, alkyl, acetyl, hydroxyalkyl,or --(CH₂)_(n) R₃₅ ; and their pharmaceutically acceptable salts.
 2. Thecompound of claim 1 where R₂₀ is a group represented by formula (U) or(V) and R₂₄ is R₃₀.
 3. The compound of claim 2 where R₁₀ is a grouprepresented by formula (A) and R₁ is alkyl.
 4. The compound of claim 3where R₃ is H or alkyl; R₄, R₅, R₁₅, and R₁₆ are H; and R₁₃ is H, halo,or alkyl.
 5. The compound of claim 4 where R₃₀ is --NH*, --NH*SO₂ R₃₁,or --NH*SO₂ NR₃₂ R₃₄.
 6. The compound of claim 5 where R₁ is Me; R₃ is Hor Me; R₁₃ is H; and R₁₄ is H, halo, alkyl, alkylthio, or alkoxy.
 7. Thecompound of claim 6 where R₁₂ is H, F, Cl, Me, OMe, or OH; and R₁₄ is H,F, Cl, Me, OMe, or SMe.
 8. The compound of claim 7 where R₂₀ is a grouprepresented by formula (U); R₂₃ and R₂₅ are H; and R₂₂ and R₂₆ areindependently H, halo, or cyano.
 9. The compound of claim 8 where R₁₄ isH, Me, Cl or OMe; and R₂₂ and R₂₆ are independently H, F, Cl, or CN. 10.The compound of claim 9 where R₂₆ is H.
 11. The compound of claim 10where R₃₀ is --NH*SO₂ R₃₁.
 12. The compound of claim 11 where R₃₁ isalkyl, hydroxyalkyl, or --(CH₂)_(n) R₃₅.
 13. The compound of claim 12where R₃₁ is Me or 2-hydroxyethyl.
 14. The compound of claim 13 where R₃is H; R₁₂ and R₁₄ are Me; R₂₂ is F; and R₃₁ is 2-hydroxyethyl, namelyN-{3-fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.15. The compound of claim 13 where R₃ is H; R₁₂ and R₁₄ are H; R₂₂ is F;and R₃₁ is 2-hydroxyethyl, namely N-{3-fluoro-4-5-benzoyl-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.16. The compound of claim 13 where R₃ is H; R₁₂ is H; R₁₄ is Me; R₂₂ isF; and R₃₁ is 2-hydroxyethyl, namely N-{3-fluoro-4-5-(4-methylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!phenyl}-2-(hydroxy)ethanesulfonamide.17. The compound of claim 10 where R₃₀ is --NH*SO₂ NR₃₂ R₃₄.
 18. Thecompound of claim 17 where R₃₂ is H; and R₃₄ is H or acetyl.
 19. Thecompound of claim 18 where R₃ is H; R₁₂ and R₁₄ are Me; R₂₂ is F; andR₃₄ is H, namely 1-{3-fluoro-4-5-(2,4-dimethylbenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!-phenyl}sulfamide.20. The compound of claim 10 where R₃₀ is --NHH*.
 21. The compound ofclaim 20 where R₃ is H; R₁₂ and R₁₄ are Me; and R₂₂ is F.
 22. Thecompound of claim 7 where R₂₀ is a group represented by formula (V); R₁₄is Me, Cl, or OMe; and R₂₂ is H, F, or Cl.
 23. The compound of claim 22where R₃₀ is --NH*SO₂ R₃₁.
 24. The compound of claim 23 where R₃₁ isalkyl, hydroxyalkyl, or --(CH₂)_(n) R₃₅.
 25. The compound of claim 24where R₃₁ is Me.
 26. The compound of claim 25 where R₃, R₁₂, and R₂₂ areH; and R₁₄ is OMe, namely N-{2-5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-ylmethyl!pyridin-5-yl}-methanesulfonamide.27. The compound of claim 22 where R₃₀ is --NH*SO₂ NR₃₂ R₃₄.
 28. Thecompound of claim 27, where R₃₂ is H; and R₃₄ is H or acetyl.
 29. Thecompound of claim 22 where R₃₀ is --NHH*.
 30. The compound of claim 29where R₃, R₁₂, and R₂₂ are H; and R₁₄ is OMe.
 31. A pharmaceuticalcomposition comprising a therapeutically effective amount of a compoundof claim 1 and a pharmaceutically acceptable excipient.